Multiple Sclerosis Ever Changing
Multiple Sclerosis Everchanging. Trials, experiments, medications, research, scientists, . A blog of a real patient, his details on how MS keeps him actively looking for items that help, real time research, articles with links to university experiments, drug manufacturers experiments, bloggers, and more
Everchangingms.blogspot.com
Seems my blogs get far and few. Many reasons. More Specialized Doctors added, some top of the top working with me. I had the pleasure of meeting one, who came out of retirement, to work his specialized clinic once per month. A six month wait to get to talk with the Dr, and two others, plus student learning, as I was listening also.
These Drs specifically specialize in one field. Like one box you do not stray from. So he did not know of other diseases, just generally. I was his first MS Patient in all his years.
Excellent at his knowledge. That was what he was teaching me in the hour spent. He did a lot of reflexes and watched me walk, talk, movements. A new toy to "try" for five minutes a day, perhaps 15 minutes. That was the only thing left he could offer.
My MS specialist is awaiting a new mylan repair medicine.
The Day before, I saw my MS Botox neurologist. He had a new Dr with him. I let the new Dr put the botox into my muscles. He was not afraid to ask for assistance finding muscles, asking my main Dr there. I look forward, as these shots help me stay active and walking. I have to sign a Black Box Warning for this medivine.
I have been seeing this top dr in his field and his co Specialist and his team for this last year. They were able to bring my blood pressure and all readings into a normal range. half of what it was.
I brought my iron up into normal range, by stopping curcumin turmeric for a day, eating beef liver ( high in Iron ) and back onto supplement. Retested, and my being iron deficient for three years after my phlebotomy or vein puncture, all went away.
Yes a DROP in blood readings
Now I am not a Dr, but would of liked to of been a birdie listening in on how Drs (in their own boxes) can disagree on symptoms and what even their test may say is going on with me. The phone call to all these other Experts in their own field., and their perspective, or what left is a option.
All I can share now is I have Primary Progressive Multiple Sclerosis. This is effecting my whole body, in ways I would never imagine. Hereditary Hemochromatosis with the H63D H63D gene playing a role, overlapping Endocrinologist, hematologist, Neurologist,GI, nephrologis,, and 23 more to list. That are overseeing My Multiple Sclerosis. A good team. The Best of the Best.
I still walk with a cane. Minds active. get around, fatige real easily. Research what Dr, their thoughts, brings me back to a reality, shared with only a few this entire year, of what they see, or know. The changes a reality.
A Topic, I have not blogged much on, is the sleep cycle. There is a known item called Sleep deprivation also.
I have experienced this since before being diagnosed with Multiple Sclerosis. But this is part of Multiple Sclerosis, and a bunch of other disorders.
This According to Wikipedia,
"Sleepis anaturallyrecurring state of mind and body, characterized by alteredconsciousness, relatively inhibited sensory activity, reducedmuscleactivity and inhibition of nearly allvoluntary musclesduringrapid eye movement(REM) sleep,[1]and reduced interactions with surroundings.[2]It is distinguished fromwakefulnessby a decreased ability to react tostimuli, but more reactive than acomaordisorders of consciousness, with sleep displaying different, active brain patterns.
Sleep is associated with a state of muscle relaxation and reduced perception of environmental stimuli.
Sleep occurs in repeating periods, in which the body alternates between two distinct modes: REM sleep and non-REM sleep. Although REM stands for "rapid eye movement", this mode of sleep has many other aspects, including virtual paralysis of the body. A well-known feature of sleep is the dream, an experience typically recounted in narrative form, which resembles waking life while in progress, but which usually can later be distinguished as fantasy. During sleep, most of the body's systems are in an anabolic state, helping to restore the immune, nervous, skeletal, and muscular systems;[3] these are vital processes that maintain mood, memory, and cognitive function, and play a large role in the function of the endocrine and immune systems.[4] The internal circadian clock promotes sleep daily at night. The diverse purposes and mechanisms of sleep are the subject of substantial ongoing research.[5] Sleep is a highly conserved behavior across animal evolution.[6]"
I can only tell you of my experience of sleep with being diagnosed with multiple sclerosis. I am not a Doctor, but rely on them with many questions.
Most over the counter items have been tried. Check with your Doctor, before doing this, as some may interact with medicines.
Many multiple sclerosis medicines will can make you sleepy. But being able to sleep at the right time is a necessary evil that can transform into sleep deprivation.
I even tried items to help you sleep. Many are availiable by Google search, or youtube.com binerial beats at different frequencies was interesting. The sleep talk, to make you feel sleepy, or the pitter patter of rain drops, to the ocean, or a campfire sometimes helps. Making sure your room is for sleep.
"Sleep timing depends greatly on hormonal signals from the circadian clock, or Process C, a complex neurochemical system which uses signals from an organism's environment to recreate an internal day–night rhythm. Process C counteracts the homeostatic drive for sleep during the day (in diurnal animals) and augments it at night.[27][23] The suprachiasmatic nucleus (SCN), a brain area directly above the optic chiasm, is presently considered the most important nexus for this process; however, secondary clock systems have been found throughout the body."
My circadian clock was real messed up.
But when all these fail, your Doctor may prescribe medicines. Drug companies may have you do what they call "Step Therapy". This is usually a process to make you fail, using inferior medications, perhaps a copy of the real medicine, or combinations.
After using a dozen, perhaps more, that included lunesta, and many other generic sleep meds. at least thirteen other companies make this. All they need is 75% of the active ingredient for a generic medication. I was switched to many sub standard companies, before I requested name brand Ambie, then went to Ambien ER in 2013.
This has happened with other meds that went to generic versions. Some had detrimental effects on me, that I need the name brand.
Recently, the worlds largest pharmaceutical company bought out contracts from other boxed stores, making them the only player for the consumer to buy from. They Stopped carrying Ambien, with a phone call from their customer service Center, asking me, what I wanted to switch to. I asked if she was a dr, and she said no. I told her I was not a Dr either, so she would have to contact my Dr.
The largest company, Express Scripts, was just bought out by Cigna.
Then it started all over, of "Step Therapy Medications". Three were mentioned. I had already tried. Meds to treat my Multiple Sclerosis were stronger than the Three, per ingredients, and some would interfere with my regimen of meds. I quoted some legal items of Step Therapy to my Dr. For help of obtaining something better.
I gave her two new sleep medicines, and a third coming out, that might replace, or be as strong as Ambien, and the research sites of how they work.
DAYVIGO was chosen, and needed prior authorization, medical exemptions, which were quickly denied. More paperwork for all the above. This is where a insurance becomes a Dr without a license. A review committee, and finally a approval for my Doctor.
5 mg was not strong enough a week later, so my Dr requested 10 mg.
This works differently than ambien. But will have to let you know. I keep a sleep tracker on my watch, a inspire. It gives me scores of sleep, deep, light, Rem, and much more information I can show my Doctor. Example below.
Much more information is availiable. Many watches and apps were tried, before this was purchased, which show sleep.
Quviviq-new-sleeping-pill is the newest sleep aid being tried, June 2022. Clicking on this will give you more info than I can, and I will have to do a update on each of these pills.
DAYVIGO gave me vivid dreams, but the maximum dose still did not get me the Quality of sleep I need.
I have been to three sleep studies, two overnight at UC Davis. Many electrodes placed on your head and body. its like being cloned, as they measure all these elements. I do not have sleep apnea, a condition of snoring. A Cpap machine helps many.
I think I am a test subject, due to my primary progressive Multiple Sclerosis, and hereditary Hemochromatosis caused by two rare DNA H63D genes, that caused Iron Overload.
my regimen consist of over twenty Nine medications, counted out for daily use. Each designed for the multitude of MS symptoms, and therapies that have been added on... including Botox into my calves, thighs, neck and shoulder muscles. Many of the meds make me sleepy, so to combat that Prohibit is used during the day, to give me a few hours for the quality of life.
I was diagnosed with Primary Progressive Multiple Sclerosis a decade ago it seems. Copaxone was one of the only Disease Modification Therapies, "DMT" availiable for me.
I've hit everything on this list above plus more. Each are additive, so you never get better.
My double vision, was just a ongoing part of optic neuritis to this date. Clenched fist, a old time heart medicine, clonidine, was used to for my MS. It released my clenched hands up.
My first real neurologist specialized in MS., was out of my county, referred by a smart country Dr, who had dogs and birds in his office. i New his animals by nane.
Even though the local bandage hospital in my county had put NO MS in large print, the lady who read all the MRI, had no experience with MS. I asked for a copy, this is when they were still on large film images. Many were taken. My local GP, said " they did not go far enough". This is before I knew he suspected MS.
The new neurologist was a smart guy who listened, short in words though. He looked at my images, and said they took some great ones. He then scheduled me for a Spinal Tap the next day in his office. Yes a skilled surgeon, he did this procedure, with me lying flat on my stomach.
I can not go into graphics, as could not see the big vial of spinal fluid taken out, or other instruments used to keep pressures proper, just told to keep still. Yes you feel size of needle penetrate the skin, but that was all, as area was pre numbed.
Many more blood test were taken to rule out anything else other Drs may of missed.
I went home, kept laying down, keeping hydrated all day. Had no problem.
The next visit, to go over the results, of what he found in my spinal fluid, was parts of the Mylen floating around. Brain matter suggestion of MS. The lesions on the MRI, of one old one and three active ones, were as clear as day, if you knew what you were looking for. He showed me on the film.
He thought I had MS going in for some time, looking at first lesion. But I was diagnosed fast. First year i was mis diagnosed of Cryps. chronic regional pain syndrom. A year on opiioids and enough morphine, the pharmacist thought I was picking it up for someone on their deathbed. This all change with the proper diagnosed primary progressive Multiple Sclerosis, along with degenerative disk disease.
I was weaned off the morphine and opioids. Lyrica and cymbalta are used to treat the pain. Looking back, not all generics are the same as the real name brand. Name brand is needed.
Copaxone was started at that time, Matt had a video I watched on how to inject. He was twenty. I also started Botox treatments deep into calf muscles, as the maximum muscle relaxer, Baclofen had been used. . I have kept up with this treatment, going up on botox treatments, now being done at the University of California Davis, as amount needed, and the retirement of my neurologist.
I even went to asking my neurologist I had questions from my book on ideas, tried, or being studied. Tonic water was mentioned, because of quinine it had. I researched, and found Jeffery Morgan's recipe for making tonic from the quinine tree bark. I went over this and calculations of how much I could take to obtain results. 22 grams I shot for, or a shot glass. I did not use sugar, as weight gain from other medicines.
But quinine stopped major spasms. A conversation also got us talking about a tablespoon of mustard taken. It also stops spasms. Drs do not know why, as taken oral, and must go thru the digestive system. There are other items tried, that have worked, like taking pure turmeric curcumin, before they became in a pill and have junk put into them. A digital scale was purchased, reading down to milligrams. I found a pure INE in London finally.
Hyaluronic Acid was tried, to put space between bones. This was finally found in london, with the pure form needed, now in a pill form that works. Chrodrotion sulfide was added to help strengthen ligaments.
AlA, alla lipoic acid, was added by my UC davis neurologist. All supplements went thru my neurologist, to see if they would hep, or were just a snake cure. A supplement was given by neurologist, but on second visit, was why did the contaminate the good ingredients with a questionable one. I still get adds from this company and question their products, along with all the others, like magnesium used to assist in keeping muscles relaxed, what is its purity.
What is really in it, quality?. . vitamin D was added, as I was At rickets stage. A Endocrinologist has followed my journey. I am needing over 180,000 Iu weekly to keep a #80 score to protect my MS, as this shows to be the best protection at a dose #80-100, but keeping calcium out.
I am also on Testosterone Therapy. Many Priorblogs will show this. Used to keep muscles going with me, but also can be related to thick blood. The cancer center took DNA checking to find iron overload to add to my ever growing list. A Rare H63D geems. They thought It was the testosterone therapy, as had been on mega amounts, due to a oversight of a decimal point. But a quick stop to this, and six months to get it out of my system, a MRI of the pituitary gland showed I was low. On small amounts till they figure my thick blood out.
That is a problem.
Guess this is where I stop your reading, letting you go back in time to read other blogs. I have posted some great videos about how blood is made, heartbeats, and phlebotomy done, MS symptoms and guess what's not posted yet.
in one of the forums, polycythemia was mentioned. i asked some questions, and think i gave the person enough information to ask her Doctor, as Multiple Sclerosis may of been plausible for what my blog was saying, and what was told.
Everchangingms.blogspot.com I could go and try to explain How Red blood cells are formed, how this relates to my H63D gene mutation, and how this relates to Multiple Sclerosis, Iron overlaod, Thick blood, but I think its better described by this guy.
you dont need to be a scientific person, or even know the terms he talks about. Just follow the video, the best you can. this will give you questions to ask your Doctor, or a understanding of what your Doctor is talking about.
polycythemia, thick blood, hereditary Hemochromatosis, gene mutations, blood letting, vein punctures, phlebotomy, or just low in iron? Multiple Sclerosis, or a wide range of items that comes with MS?
this is Part One of two parts of blood formation. i have this guy on other Videos, to explain my blood,
Expert Doctors I go to at the University of California Davis, USA
Many genes are tied to Multiple Sclerosis. Hereditary Hemochromatosis runs in both my family lines. hard to get people to understand. Many Specialized Doctors and Science looking into this on me. They know as far as their specific specialized medicine, so you need to put the parts together sometimes. I use them all as team members, letting each one know of a part they have found. Its always something new, and some blogs, I still need more input and test done to find out more.
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But thats the blog this week.
happy holidays to those around the world and remember to join my blog, and follow me
Back to this pesky H63D gene needing to write again on.
This does concern the Primary Progressive Multiple Sclerosis disease I was given in 2012, and the multitude of diagnosis that came afterwards, all inter related. I hope some scientist can figure this out.
Pro570Ser - risk allele: T (Pro589Ser) This is called TF C2. It creates an increased likelihood of iron loading when combined with any c282y and h63d because it forces a reduced TIBC resulting in higher levels of free iron and free radicals. This also Increases susceptibility to Alzheimer's disease but only when combined with c282y.
But I have two copies of H63D, that one less than 3% get iron overloaded.
This gene has been With me my entire life. It is hereditary.
Hemochromatosis is one of the diagnosis in 2018. Thick blood, that the endocrinologist sent me to the Cancer Center. It took them a few DNA searches to find, but two pair. Less than 3% have Hemochromatosis caused by this gene. My Iron, Hemoglobin, Hematocrit, Transferrin were high, along with Hypertrycglimeria stage I was in.
17 phlebotomy or vein punctures for my Europe readers were done last quarter of 2018.
Two years later, no iron has returned (or a little, since they allowed me to use cast iron skillet again, and spinach) but iron still low, barely on the chart.
My blood was thicker than pancake batter.
Does this still make me anemic two years later? Depends on which Doctor you talk with
Is this being anemic for two years? I kept doing my blood labs every two months. with iron not moving. The hemoglobin is on high side now. So does this make me iron deficient?
Lots of questions, so asked my medical team.
Ferritin 13, iron 49, Transferrin 305H, Total iron binding 424H, Iron sat11.6% low. This is two years after phlebotomy Erythropietin was 25H. Creatine still high, along with Tryglicerdimia
As anemic, has its own set of problems, and other diagnostic items of what it can damage, and so does low iron, and MS.
I belong to a Hemochromatosis group. had family checked, as hereditary. Found two others given diagnostic from this pesky gene. I asked to become a member of anemia group, and iron group to find out more of what came first?
What if I had anemia my whole life, but it was drowned out by Hemochromatosis, and MS? I found a site, https://www.anemiaid.com/
This will check your DNA for free. I sent request to my cancer Dr.
I also found interesting info from these sites I emailed my Dr team.
My GI symptoms went south when I had my last phlebotomy. He did not see coordination of iron playing a role. He is a great GI Dr. Linzess along with laculose was given. He informed me from my last upper and lower GI, that I did not have ulcerative colitis, but IBS-C. He did more test to verify this. A breathing test to check for hydrogen. Used l lactulose, so had to be off this for a week. Constipation. A emptying test.
I have also had a swallowing test, that showed problems. Eating radioactive food, never sound appealing.
I am also on metoclopramide, as my MS is not giving my bowel muscles the proper signal to muscles to move food along. This was also tested, by going off this medicine for months, and being put back on. I call this a Black Box medicine, as may interfere with my other meds. My drug company always has to check with GP, Neurologist, and GI Dr to get ok.
But GI problems go with MS, hand in hand. However, if you do not have iron, another story.
Iron is a absorbed in the lower intestine.
I have problems absorbing items there, as a test with vitamin D was done, with the assistance of my endocrinologist. I was able to take 50,000 iu/day less tablets, by just changing time of day taken. A oil pill, like Vascepa, but interference with some genes and possibility meds.
Not that Iron is the solution, but why am I not absorbing from foods, cast iron skillets?
If regular Hemochromatosis, I would be making new red blood cells every four months. The bone marrow, would tell this. Also I would need to give blood every three months for Hemochromatosis levels.
So not to go into any new diagnosis given, I asked my team at UC Davis to check on more items. This may add a new team member, but that's for another blog.
Would love feedback from anyone.
Stay health and safe. Be sure to like my blog and YouTube channel.
This amino acid is very important in gut healing. Glutamine helps to maintain the integrity of the intestinal wall and therefore aides in leaky gut. With less intestinal permeability means less microbes can get through the gut wall, decreasing infections. It is also fuel for hepatocytes, improving liver function.
Zinc is involved in many biochemical processes in the body including protein and DNA synthesis, carbohydrate metabolism and antioxidant systems. It is therefore important for effective digestion. Wound healing and normal immune responses require zinc, so it is great for IBS sufferers and their overall health. Zinc deficiency has also been linked to depression. Zinc supplements can cause nausea on an empty stomach so please ensure you take it with food. Foods high in zinc include all meats, pumpkin seeds, eggs, and seafood
Magnesium like zinc is one of those nutrients that is part of hundreds of processes in the body. The main ones that affect IBS are:
While calcium contracts muscles, magnesium relaxes them, so for those with cramps this is important to make sure your body has the resources to relax muscle. Magnesium can help reduce discomfort and pain caused by cramping.
Stress and anxiety use up a lot of magnesium. These have been identified as trigger in many people with IBS, so it is very important to maintain good levels of magnesium, so you don’t get depleted.
Magnesium is also used for sleep and relaxation so very important for everyday wellness.
You can take magnesium as a supplement but be careful with the form of magnesium that you take. Magnesium oxide is the most common form found in supplements but is used for bowel cleansing as it is not well absorbed. Look for magnesium citrate, chelate and malate
Magnesium rich foods include almonds, avocado, and figs. These foods are all high FODMAP, so as IBS sufferers are often avoiding these foods, this can often lead to low magnesium. Some low FODMAP foods high in magnesium include spinach, pumpkin seeds and Brazil nuts.
Vitamin B6.
Vitamin B6 is also known as pyridoxine. B6 is absorbed in the small intestine, so problems with absorption can occur in those with IBS. B6 is very important for mental health as it is used to make serotonin, dopamine and GABA neurotransmitters, basically all of the happy hormones. As mental health is an important part of IBS treatment B6 is crucial.
Iron and B12
Many people with IBS end up with iron-deficient or B12-deficient anemia because of issues with absorption. Those with IBS-D are especially susceptible as this causes absorption to be low. With the high levels of inflammation often present with IBS, this can cause the digestive system to be unable to absorb both iron and B12.
The H63d genes I have, play into this. I absorb iron from both these genes, making phlebotomy or vein puncture needed to get rid of iron,
But then dangers of being anemic, I will blog about later.
I’m lumping them together here as they often go hand-in-hand and while not essential for treatment of IBS per se, they are important nutrients to keep an eye on, so you don’t have further health complications. Therefore, if you are feeling tired and fatigued all the time make sure you check your iron and B12 levels. Make sure you get appropriate testing and consult your medical professional before taking iron or B12 supplements.
As always, consult your health professional before taking any supplements.
Multiple Sclerosis and food, Diets. You can Google and get every type of diet out there.
The current Fad Diets, like keto, not proven.
i tried being being sugar free. Less than 4 grams per day. Sure lets you become aware of how much sugar is in everything, and also hidden sugar. Even yougurt was off the list, milk, and a ton of other items by reading and understanding lables, and how they hide the sugar now. becoming a vegan, going gluten free, milk free, and many more explored.
Many multiple sclerosis meds cause weight gain, almost overnight. I am not exempt from this.
My GI Dr suggested the food map diet. Eliminating everything and adding it back in slowly to see what bothers your GI system. I went a step ahead, did a DNA, that showed foods to avoid, super foods, and cautious ones. This seemed a no brainer, with probiotics, vitamins, and recommendations made by viome.com, and my nutritonalist.
The food map was interesting, and kinda exciting finding super foods, and ones to avoid, or bring back slowly.
Canker sores. Research shows that applying a gel containing berberine can reduce pain, redness, oozing, and the size of ulcers in people with canker sores.
Diabetes. Berberine seems to slightly reduce blood sugar levels in people with diabetes. Also, some early research shows that taking 500 mg of berberine 2-3 times daily for up to 3 months might control blood sugar as effectively as metformin or rosiglitazone.
High levels of cholesterol or other fats (lipids) in the blood (hyperlipidemia). Berberine might help lower cholesterol levels in people with high cholesterol. Taking berberine for up to 2 years seems to reduce total cholesterol, low-density lipoprotein (LDL or "bad") cholesterol, and triglyceride levels in people with high cholesterol. When compared with standard cholesterol-lowering medications, berberine appears to cause similar changes in total cholesterol, LDL cholesterol, and high-density lipoprotein (HDL or "good") cholesterol, and it might be better at reducing triglyceride levels.
High blood pressure. Taking 0.9 grams of berberine per day along with the blood pressure-lowering drug amlodipine reduces systolic blood pressure (the top number) and diastolic blood pressure (the bottom number) better than taking amlodipine alone in people with high blood pressure.
A hormonal disorder that causes enlarged ovaries with cysts (polycystic ovary syndrome or PCOS). Research shows that berberine can lower blood sugar, improve cholesterol and triglyceride levels, reduce testosterone levels, and lower waist-to-hip ratio in women with PCOS. Berberine may even lower blood sugar levels similar to metformin and may improve cholesterol levels better than metformin. It is unclear if berberine increases pregnancy rates or live birth rates in women with PCOS.
1: Reduces Cholesterol and Triglycerides
Significantly and Safely
Big Pharma has created a multi-billion-dollar industry around controlling cholesterol and triglycerides with a "solution" that too often negatively impacts other aspects of your health.
Thankfully, berberine can come to the rescue. One study of participants with elevated cholesterol and triglyceride levels reported that taking 1,000 mg of berberine daily for three months led to a remarkable 25% drop in LDL and a 35% drop in triglycerides—as well as a 29% reduction in total cholesterol—with no side effects.[1]
Another study found much the same. In this second trial, scientists recorded a 21% reduction in LDL, a 36% reduction in triglycerides and an 18% reduction in total cholesterol—just by taking 1,000 mg daily for three months.[2]
And here's another reason why berberine is such an extraordinary antioxidant...#2: It Dramatically Improves Metabolism,
Promotes Weight Loss and Boosts Energy
How Effective is Berberine for Weight Loss
"Berberine has already passed a handful of important demonstrations of efficacy. In 2012, for example, one study showed that obese human patients lost an average of 5 lbs over the 12-week course of treatment.4 While these results may seem modest, there’s more to the story. Significantly, the patients in the trial experienced a 23% drop in their soluble triglyceride levels and a 12.2% drop in their cholesterol levels beyond what would be expected from weight loss alone. This means that berberine helped the patients lose weight while simultaneously reducing the harmful chemical correlates of being overweight; high triglyceride and cholesterol levels are associated with many of the negative health outcomes of being overweight. As such, berberine provided valuable protection of overall health."
The supplemental benefits of berberine are best taken advantage of by people who are concerned about their metabolic health, want to reverse the negative health effects of obesity, or who want a chance at improving their blood glucose regulation and fight back against metabolic dysfunction.
It’s been studied most intently as a way to help treat insulin insensitivity in people who have type two diabetes or who have metabolic syndrome. However, berberine also finds applications in helping with other health issues commonly associated with an unhealthy diet and excessive body weight, such as high cholesterol and high blood lipids.
While berberine is not, on its own, a fantastic weight loss supplement, it does do a fairly good job helping to ameliorate the negative health effects associated with being overweight. It might help lower your body fat percentage, but it’s far stronger at improving health than just reducing the number that you see on the scale.
Some research suggests that berberine works for weight loss, but not as well as some of the more high-powered compounds for weight loss like green tea extract. Its real strength lies in changes to your body’s metabolic health. So taking berberine might be helpful as you are trying to lose weight, so you can move your body closer to a metabolically healthy state.
Interestingly, berberine also has a dedicated core of advocates among people who have irritable bowel syndrome. While the mechanism of action here is not entirely clear, clinical research does support the use of berberine to reduce some of the symptoms of irritable bowel syndrome, so if you have gastrointestinal problems attributable to IBS, you may have success using berberine as well.
https://bodynutrition.org/berberine
https://www.stopagingnow.com/berberine56
Alpha lipoic acid is another one I am on.... Like many prescribed by my neurologist.
Alpha Lipoic Acid (ALA) is a vitamin-like compound that is used in the body to break down carbohydrates and generate energy for the body’s organs
Natrol® ALA is also an antioxidant, a substance that neutralizes potentially harmful chemicals called free radicals and thereby helps prevent cell damage in the body. What makes alpha lipoic acid unique is that it functions in both water and fat unlike the more common antioxidants such as vitamins C and E, and it is able to re-cycle antioxidants such as vitamin C and vitamin E after they have been used up.
Alpha-lipoic acid can improve the function and conduction of neurons in diabetes, as well as help with memory loss and mental acuity.
Taurine plays an essential role in metabolism and digestion, as it helps the liver to create bile salts. Bile salts help break down fatty acids in the intestines. Bile acids are the body's main way of breaking down cholesterol.
Mutations in HFE Causing Hemochromatosis Are Associated with Primary Hypertriglyceridemia
The diagnosis is made on blood tests, often performed as part of screening. Once diagnosed, other blood tests are usually required to determine whether the raised triglyceride level is caused by other underlying disorders ("secondary hypertriglyceridemia") or whether no such underlying cause exists ("primary hypertriglyceridaemia"). There is a hereditary predisposition to both primary and secondary hypertriglyceridemia.[1
How the body digests and absorbs fat
Biologically speaking, the purpose of eating is to gain energy, nourishment, and building blocks for the body to continually renew itself. Fats are a great source of energy because, at 9 calories per gram, they have more than twice the energy potential of carbohydrates, and they do not cause cardiac events. But they do more than just supply energy.
Fats are the building blocks of phospholipids, key components of cell membranes. Fats store energy, and their components serve as intracellular messengers and help to manufacture hormones. Most of the fat we eat is in the form of triglycerides, which are large molecules. The body uses lipase enzymes to break them down into smaller particles. Most lipid digestion in an adult occurs in the upper loop of the small intestine, where a pancreatic lipase does the work. Fats may differ from each other by virtue of carrying different fatty acids, which may be saturated or unsaturated.
When we eat fat, stomach emptying slows and a small amount of fat is treated by gastric lipase in the stomach. This holds especially true for saturated fats, like those in butter.
The liver produces bile, stored in the gallbladder, ready to be shot into the small intestine when the fat gets there. Bile emulsifies the fat and introduces it to pancreatic lipase, whose job is to digest the triglycerides into free fatty acids and monoglycerides, which are then absorbed into the small intestine under typical circumstances.
Fat malabsorption symptoms
At the most basic level, fat malabsorption is a decreased ability for the intestines to absorb needed fats.
The signs and symptoms that someone who is lacking sufficient enzymes to digest and absorb fats may
bloating
gas
feelings of fullness
stomach cramps
diarrhea
pale-colored stool
floating stool
erratic bowel movements
Failure to absorb fats will likely engender additional symptoms, including:
dry hair and skin
premature skin aging
weak nails
sore joints
Where fatty acids are concerned, it also affects:
moodiness
anxiety by
depression
impaired cognitions
allergic or atopic conditions - eczema, ast byhma, hay fever
sleep problems
You may also see low levels of cholesterol, triglycerides, HDL, and LDL in your blood test results.
What are the health benefits of taurine? The most important role that taurine plays in the body is assisting with metabolism and digestion. Taurine is known to aid the body in the development of bile salts, which are ultimately used by the body to metabolize fats within the digestive system and thus can decrease the acquisition of body fat.
Some studies also note a connection between heart health and taurine consumption, as taurine has been connected to a decrease in cholesterol levels and an increase of positive heart functioning. Additionally, like many amino acids, taurine plays a role in muscle maintenance and development. The effects that taurine has on the heart and muscles can result in improved athletic performance and focus during workouts. Taurine also has been shown to improve mental focus, making it a powerful pre-workout agent.
Is taurine bad for your kidneys? Taurine is an important amino acid that plays a significant role in kidney functioning. Oftentimes, taurine is administered to those with kidney disease or decreased kidney functioning to improve their functioning. Taurine has even been prescribed as a treatment method for those suffering from diabetic nephropathy, which affects the kidneys (11).
Another blog is needed about Green Tea and Matcha. I will have to go into later, as this is getting extensive to understand, but each of these plays a role in Multiple Sclerosis and the Gut. This is More for me to find quick links, and of course to ask your Doctor before trying any of these.
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Why even call or say something like this? Seems strange on its own, but I. Am sure everyone can relate.
"The life cycle of a Painted Lady butterfly is approximately three weeks. Female butterflies usually lay their caterpillar eggs around 5-7 days after emerging from their chrysalis. Baby caterpillars hatch from the eggs after three days. The growing caterpillars will then eat for 10-12 days before forming their own chrysalides. Finally, adult butterflies will emerge from the chrysalides after 7-10 days, starting the life cycle all over again!"
What does this have to do with MS? There is a term used like I have "butterflies in my stomach", usually referring to the unknown, or a churning feeling given at any moment. This can manifest into the above cycle of learning, exploring, and redoing the same as new items are found.
RimabotulinumtoxinB (Myobloc), also called botulinum toxin type B, is made from the bacteria that causes botulism. Botulinum toxin blocks nerve activity in the muscles, causing a temporary reduction in muscle activity.
Myobloc is used to treat cervicaldystonia (severe spasms in the neck muscles).
I have many unknowns with Primary Progressive Multiple Sclerosis. This includes waking up with shooting zaps from my legs and neck muscles, wondering if they will support me. On other blogs, I talk about the
Black Box Warning.
This is for botulinum toxin type b I recieve every three months. Its cycle is like a butterfly. Mine is injected with fine needles into many muscles of my calves, neck and thigh muscles. The botulinum toxin then starts to spread over the next few weeks, making its cycle of reproduction into, deadening overactive muscle nerves that are part of my Multiple Sclerosis sending to them erroneously.
symptoms can also occur in adults treated for spasticity and other conditions, particularly in those patients who have underlying conditions that would predispose them to these symptoms. In unapproved uses, including spasticity in children and adults, and in approved indications, cases of spread of effect have occurred at doses comparable to those used to treat cervicaldystonia and at lower doses.
The botulinum toxin continues its life cycle, for me, lasting about 52 days. Short of the 90 days, that is required to wait for the next injections, or new cycle to begin.
Even on with a computer guidance system, the professor of the Neurological department, knows which muscles, injections, spots, muscle names, and where he is trying to obtain the best result, using the entire allotted amount of botox in many sites.
Of course, not all sites get addresses at a single visit. It takes time for the botox to multiply and travel into and thru the muscles. A Cane helps me walk into and out of his office, feeling immediately the botox injection.
A black box warning
The botulinum toxin contained in this medication can spread to other body areas beyond where it was injected. This can cause serious life-threatening side effects.
This is where the benefits outweigh the risks for me. A special form is signed by me before the neurologist can inject.
A weird process to look forward to, that I just had done, and done since the beggining of my diagnosis, every three months.
And the butterfly process begins again.
As far as butterflies in my stomach, is always the unknowns. I can research many items. Some outside my control, some just numbers that specialists look at from blood work.
There are items I share with my Neurologist, I will post links in another blog to keep you reading. They thank me for the links, as it pertains to the Rare H63d genes I have, and also to specific topics. You (my audience) gets to wait until I see the proper specialists, so I can obtain their perspective.
Anyways, thanks for reading!
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