Search This Blog

Showing posts with label sleep disorders. Show all posts
Showing posts with label sleep disorders. Show all posts

Wednesday, April 6, 2022

Sleep and MS, or Sleep awake Cycle, sleep deprivation



 A Topic, I have not blogged much on, is the sleep cycle. There is a known item called Sleep deprivation also.

I have experienced this since before being diagnosed with Multiple Sclerosis. But this is part of Multiple Sclerosis, and a bunch of other disorders.


This According to Wikipedia, 

"Sleep is a naturally recurring state of mind and body, characterized by altered consciousness, relatively inhibited sensory activity, reduced muscle activity and inhibition of nearly all voluntary muscles during rapid eye movement (REM) sleep,[1] and reduced interactions with surroundings.[2] It is distinguished from wakefulness by a decreased ability to react to stimuli, but more reactive than a coma or disorders of consciousness, with sleep displaying different, active brain patterns.

A sleeping girl
Sleep is associated with a state of muscle relaxation and reduced perception of environmental stimuli.

Sleep occurs in repeating periods, in which the body alternates between two distinct modes: REM sleep and non-REM sleep. Although REM stands for "rapid eye movement", this mode of sleep has many other aspects, including virtual paralysis of the body. A well-known feature of sleep is the dream, an experience typically recounted in narrative form, which resembles waking life while in progress, but which usually can later be distinguished as fantasy. During sleep, most of the body's systems are in an anabolic state, helping to restore the immunenervousskeletal, and muscular systems;[3] these are vital processes that maintain mood, memory, and cognitive function, and play a large role in the function of the endocrine and immune systems.[4] The internal circadian clock promotes sleep daily at night. The diverse purposes and mechanisms of sleep are the subject of substantial ongoing research.[5] Sleep is a highly conserved behavior across animal evolution.[6]"


I can only tell you of my experience of sleep with being diagnosed with multiple sclerosis.  I am not a Doctor, but rely on them with many questions.

Most over the counter items have been tried. Check with your Doctor, before doing this, as some may interact with medicines.

Many multiple sclerosis medicines will can make you sleepy.  But being able to sleep at the right time is a necessary evil that can transform into sleep deprivation.

I even tried items to help you sleep. Many are availiable by Google search, or youtube.com  binerial  beats at different frequencies was interesting. The sleep talk, to make you feel sleepy, or the pitter patter of rain drops, to the ocean, or a campfire sometimes helps.  Making sure your room is for sleep.

"Sleep timing depends greatly on hormonal signals from the circadian clock, or Process C, a complex neurochemical system which uses signals from an organism's environment to recreate an internal day–night rhythm. Process C counteracts the homeostatic drive for sleep during the day (in diurnal animals) and augments it at night.[27][23] The suprachiasmatic nucleus (SCN), a brain area directly above the optic chiasm, is presently considered the most important nexus for this process; however, secondary clock systems have been found throughout the body."

My circadian clock was real messed up.

But when all these fail, your Doctor may prescribe medicines. Drug companies may have you do what they call "Step Therapy".  This is usually a process to make you fail, using inferior medications, perhaps a copy of the real medicine, or combinations.

After using a dozen, perhaps more, that included lunesta, and many other  generic sleep meds. at least thirteen other companies make this. All they need is 75% of the active ingredient for a generic medication. I was switched to many sub standard companies, before I requested name brand Ambie, then went to Ambien ER in 2013.

This has happened with other meds that went to generic versions.  Some had detrimental effects on me, that I need the name brand.

Recently, the worlds largest pharmaceutical company bought out contracts from other boxed stores, making them the only player for the consumer to buy from. They Stopped carrying Ambien, with a phone call from their customer service Center, asking me, what I wanted to switch to. I asked if she was a dr, and she said no. I told her I was not a Dr either, so she would have to contact my Dr.

The largest company, Express Scripts, was just bought out by Cigna.

Then it started all over, of "Step Therapy Medications". Three were mentioned. I had already tried. Meds to treat my Multiple Sclerosis were stronger than the Three, per ingredients, and some would interfere with my regimen of meds. I quoted some legal items of Step Therapy to my Dr. For help of obtaining something better.

I gave her two new sleep medicines, and a third coming out, that might replace, or be as strong as Ambien, and the research sites of how they work.

DAYVIGO was chosen, and needed prior authorization, medical exemptions, which were quickly denied.  More paperwork for all the above.  This is where a insurance becomes a Dr without a license.  A review committee, and finally a approval for my Doctor.

5 mg was not strong enough a week later, so my Dr requested 10 mg.

This works differently than ambien. But will have to let you know. I keep a sleep tracker on my watch, a inspire. It gives me scores of sleep, deep, light, Rem, and much more information I  can show my Doctor. Example below.


Much more information is availiable. Many watches and apps were tried, before this was purchased, which show sleep. 


Quviviq-new-sleeping-pill is the newest sleep aid being tried, June 2022. Clicking on this will give you more info than I can, and I will have to do a update on each of these pills.

DAYVIGO gave me vivid dreams, but the maximum dose still did not get me the Quality of sleep I need.

I have been to three sleep studies, two overnight at UC Davis. Many electrodes placed on your head and body. its like being cloned, as they measure all these elements.  I do not have sleep apnea, a condition of snoring. A Cpap machine helps many.

I think I am a test subject, due to my primary progressive Multiple Sclerosis, and hereditary Hemochromatosis caused by two rare DNA H63D genes, that caused Iron Overload.

my regimen consist of over twenty Nine medications, counted out for daily use. Each designed for the multitude of MS symptoms, and therapies that have been added on... including Botox  into my calves, thighs, neck and shoulder muscles. Many of the meds make me sleepy, so to combat that Prohibit is used during the day, to give me a few hours for the quality of life.

Thanks for reading.

Email me with questions anytime.

JoeY

Sunday, October 11, 2020

Fatigue and Multiple Sclerosis

 



           Fatigue and multiple sclerosis


This can be chronic, as most MS people will tell you. Fatigue for the common person or from one person to another is different.  It is hard to explain, but like you have been hit head on by a semi truck.  Sometimes just moving from one place to another is difficult, as Energy needed. Not that you don't want to do a project, just no energy, or to fatigued to do it.

My partner bought me a simple watch, but in its app it shows your fatigue level. Not sure of the algorithm used, or the accuracy of smiley faces, coffee cups. 




Quite interesting, as sleep is a factor in fatigue. 

My heart rate, EKG, Blood pressure are better monitored with a cuff, as these numbers never are accurate enough with any monitor.  I use the monitor app mainly to track sleep and steps done daily.  The Fatigue monitor,  I will have to let you know with more use.

But for me, Fatigue is daily. I have used scales, like the pain scale to monitor daily fatigue. It can hit me instantly, or I can wake up already fatigued. 

MS fatigue. It can be crushing, numbing, and stop the hardiest person in their tracks. 


"If you have multiple sclerosis (MS), you might feel very fatigued from time to time. It’s different than normal tiredness, and it doesn’t get better with sleep.

The best way to ease fatigue is to treat what’s causing it. That’s hard to do when you have MS. But you don’t need to manage your symptoms alone. Your doctor can help you figure out what triggers your fatigue. They’ll suggest some lifestyle changes that may help. You might need to treat other issues like sleep problems or depression.

If that’s not enough to ease your fatigue, medication can be an option."

This is a quote from webmd.com

I am on Provigil, as it gives me a hour more awake time then the generic modafinil.


There are many medicines out there to help keep you awake.

My Neurologist kept me off the the ones which had many side effects, or were stimulation forming. Provigil does not work on everyone though, so thus talk to your specialists of side effects, or differences of different ones to try.   There is a list of them, with new ones coming for narcolepsy that is used also.  The prescription may need a heading like, for shift work from your prescribed to be prescribed. A weird insurance issue. A Sleep Study may be required.

Provigil (modafinil) is a medication that promotes wakefulness. It is thought to work by altering the natural chemicals (neurotransmitters) in the brain. Provigil is used to treat excessive sleepiness caused by sleep apnea, narcolepsy, or shift work sleep disorders.

Provigil or Modafinil is not an amphetamine


The US Food and Drug Administration hasn’t approved any medicines to treat fatigue in patients with MS. But doctors often use amantadine, modafinil, and methylphenidate to treat fatigue in such patients.


Healthline. Com states

"Certain complications of MS can also induce fatigue. This may be referred to as a secondary cause. Complications of MS that may also cause fatigue symptoms include:

Fatigue can also be a side effect of certain medications, such as those used to treat spasticity, pain, and bladder dysfunction."

So you can see Fatigue is shown in many different aspects. 

Chronic fatigue usually becomes worse as the day wears on.   It can last for weeks, or never seem to go away.

There is a Delayed Fatigue, when major fatigue follows you for weeks, after doing a over exherting  item.  This could be a simple walk of going to far, or a exercise, mental or physical that overtires  nerves that are being misfired by Multiple Sclerosis. One of which you are left with no Energy. 

It can be acute (lasting a month or less) or chronic (lasting from 1 to 6 months or longer). Fatigue can prevent you from functioning normally and affects your quality of life. According to the National Multiple Sclerosis Society, 80% of people with MS have fatigue.

So lots of information to search for on the web, sometimes different searches will gather you more information to ask your Dr what to try. 

I still end up tired, needing a nap in the afternoon, but can tell considerable how Provigil works with me.

Questions or comments, let me know. New Year comming up, As Insurance Companies like to play Doctor.

Thanks for reading

JoeY