Vitamin B and what is effected in MS with DNA

 

Vitamin B

Image from Wikipedia

B1 is used for Metabolism.  According to Wikipedia, "Thiamine, also known as thiamin and vitamin B₁, is a vitamin, an essential micronutrient, that cannot be made in the body.^[3][4] It is found in food and commercially synthesized to be a dietary supplement or medication.^[1][5] Phosphorylated forms of thiamine are required for some metabolic reactions, including the breakdown of glucose and amino acids.^[1] "

B2,  Riboflavin, also known as vitamin B2, is a vitamin found in food and sold as a dietary supplement. It is essential to the formation of two major coenzymes...f!avin mononucleotide and flavin adenine dinucleotide  What is riboflavin and what does it do? Riboflavin (also called vitamin B2) is important for the growth, development, and function of the cells in your body. It also helps turn the food you eat into the energy you need.

B3 Niacin. It can treat high cholesterol and triglyceride levels as well as niacin deficiency. It can also reduce the risk of heart attack and slow narrowing of the arteries.

Overview. Niacin is a B vitamin that's made and used by your body to turn food into energy. It helps keep your nervous system, digestive system and skin healthy.

 key difference between vitamin B3 and B12 is that vitamin B3 is important in controlling cholesterol and triglyceride levels in our blood, whereas vitamin B12 is important as a cofactor in DNA synthesis for both fatty acid and amino acid metabolism.Niacin, also known as vitamin B3, is an important nutrient. In fact, every part of your body needs it to function properly. As a supplement, niacin may help lower cholesterol, ease arthritis, and boost brain function, among other benefits.

May reduce blood pressure. One role of niacin is to release prostaglandins, or chemicals that help your blood vessels widen — improving blood flow and reducing blood pressure. For this reason, niacin may play a role in the prevention or treatment of high blood pressure 

Vitamin B3 is a member of the vitamin family, which includes three forms of vitamers as nicotinamide, niacin, and nicotinamide riboside. Vitamin B12 is a type of vitamin involved in metabolism in our body.

what-is-the-difference-between-niacin-niacinamide/

B5. Pantothenic acid, also called vitamin B₅ is a water-soluble B vitamin and therefore an essential nutrient. All animals require pantothenic acid in order to synthesize coenzyme A – essential for fatty acid metabolism – as well as to, in general, synthesize and metabolize proteins, carbohydrates, and fats     what is B5 vitamins good for? In addition to playing a role in the breakdown of fats and carbohydrates for energy, vitamin B5 is critical to the manufacture of red blood cells, as well as sex and stress-related hormones produced in the adrenal glands, small glands that sit atop the kidneys.

B6. Vitamin B-6 pyridoxine is important for normal brain development and for keeping the nervous system and immune system healthy. Food sources of vitamin B-6 include poultry, fish, potatoes, chickpeas, bananas and fortified cereals Vitamin B6 is a vitamin that benefits the central nervous system and metabolism. Its roles include turning food into energy and helping to create neurotransmitters, such as serotonin and dopamine.Vitamin B6 is one of eight B vitamins. This group of vitamins is important for proper cell function. They help with metabolism, creating blood cells, and keeping cells healthy.  also known as pyridoxine, vitamin B6 is a water-soluble vitamin, which means it dissolves in water. The body does not store vitamin B6 and releases any excess in urine, so people need to get enough vitamin B6 every day.

B9  Folic Acid.  aids in the production of DNA and RNA, the body's genetic material, and is especially important when cells and tissues are growing rapidly, such as in infancy, adolescence, and pregnancy. Folic acid also works closely with vitamin B12 to help make red blood cells and help iron work properly in the body.

Vitamin B9, also called folate or folic acid, is one of 8 B vitamins. All B vitamins help the body convert food (carbohydrates) into fuel (glucose), which is used to produce energy.

What happens when you lack B9? Vitamin B9 deficiency can lead to anaemia and might increase your risk of heart disease. It's also really important during early pregnancy for a developing baby. Signs of deficiency include tiredness, weakness, shortness of breath, heart palpitations, and difficulty concentrating.

When you have anemia, your blood can't bring enough oxygen to all your tissues and organs. Without enough oxygen, your body can't work as well as it should. Low levels of folic acid can cause megaloblastic anemia. With this condition, red blood cells are larger than normal. It works wit B12

Folic acid helps make healthy red blood cells, which carry oxygen around the body. If you do not have enough folic acid, your body can make abnormally large red blood cells that do not work properly. This causes folate deficiency anaemia, which can cause tiredness and other symptoms.

What is Methyl Folate?
Methylfolate, sometimes known as L Methylfolate or 5-MTHF, is the active, more bioavailable form of the essential B-Vitamin Folic Acid. In order for the body to use Folic Acid, it must first be converted to Methyl Folate. 

Folic acid and folate can be cheap, but methylfolate tends to be the most effective option when it comes to treating the unique needs of MTHFR and giving the body an enzyme it can directly act upon. L-methylfolate (chemically (6S)-5-Methyltetrahydrofolate) is the most pure, active form of methylfolate you can buy.

B12 Vitamin B₁₂, also known as cobalamin, is a water-soluble vitamin involved in metabolism. It is one of eight B vitamins. It is required by animals, which use it as a cofactor in DNA synthesis, in both fatty acid and amino acid metabolism. Wikipedia. 

Vitamin B12 is a nutrient that helps keep your body's blood and nerve cells healthy and helps make DNA, the genetic material in all of your cells. Vitamin B12 also helps prevent megaloblastic anemia, a blood condition that makes people tired and weak

Methylcobalamin. Methylcobalamin is the most bio-available type of Vitamin B12 which means the body absorbs it more easily. Naturally occurring, it is found in animal-based foods such as meat, fish, milk and eggs

People sometimes ask which of the two supplements is better – the artificial (cyanocobalamin) or naturally occurring (methylcobalamin). Studies have shown that cyanocobalamin is known to absorb slightly better within the body while methylcobalamin is considered to retain better and for longer.Aug 23, 2022.

t, and eat thru your gut.ry

DNA. mthfre Gene

The MTHFR gene codes for a key 

enzyme in folate metabolism

I just so happen to have this Gene, and wrote about it before I found out I was Vitamin Deficiency of B12.  I am below 200. Neurologist wants me above 800. I went thru my entire team, to ensure the individual combinations might be of help.  It may be a double edge sword though, as thick blood cells become problematic.

Methylenetetrahydrofolate reductase deficiency is the most common genetic cause of elevated serum levels of homocysteine (hyperhomocysteinemia). It is caused by genetic defects in MTHFR, which is an important enzyme in the methyl cycle.^[1]

Thanks for reading.

Hope this will let you question each vitamin, and amount used, and why.

I did not go into full details, but a starting point.

Energy Drinks full of only certain B vitamins, that may not be the best to try

My Dr also agreed, that if I'm deficient in b12, that I am deficient in other B Vitamins.

I am not a Doctor, so check with yours before taking any supplements. Some may interfere with other meds.

A few of ones to start with. Vitamin B7, or Biotin, i stayed away from, as it effects blood test

B1 250mg metabolism

B2 as Riboflavin 100mg

B3 as Niacin 500 mg

B5 as Pantothenic Acid 500 Mg

B6 100 mg Metabolism support

B9 800 Mcg as folic Acid

B9 Methylfolate

B12 as Methylcobalamin 2000 mcg

B12 as cyanocobalamin 3000

 

SANO and Multiple Sclerosis a some of my DNA

Multiple Sclerosis

Complexity Level:Complex

mid

Heritability- medium -48% - 64%

Multiple Sclerosis (MS) is a rare autoimmune condition, caused by a body’s own immune system attacking its central nervous system.

A quick note: this article is not intended as diagnosis or treatment advice.

As well as the genes covered here, around 200 more have also been found to contribute to MS, along with environmental factors, so this is very far from being a full picture of your risk level.

i

Different variations in some of the HLA* family of genes and certain T-cell related genes have been found to relate to different levels of risk.

HIGHER RISK

LOWER RISK

rs3135388

TC

effect:3Higher risk

rs4959039

AG

effect:1.4Higher risk

rs6897932

CC

effect:1.08Higher risk

rs2104286

GA

effect:1.4Higher risk

*Read on for more detail on exactly how these genes and environmental factors like vitamin D deficiency affect MS risk.

This is my Data from SanoGenetics.com. Quite a interesting read. They picked up my Data from 23andme.com, so not a complete set of DNA used.  I have asked their permission to use this page in my blog,  as this information may help scientist and researchers.  Tellmegen.com has a  complete set of my DNA, along with Allofus.org

Vitamin D may also play a role in MS. A detailed report is available by emailing me, as I will retest to see if some items Tellmegen.com has shown interferes or not with vitamin D. 

JoeY
                     A song that I thought would fit this DNA from yester year

Time in a bottle plus the classic Sound of silence

TURKMENISTAN - WHY ARE THE STREETS SO EMPTY?

This report covers several of the genes known to play a role in Multiple Sclerosis (MS). This article is not intended as a diagnosis or to provide treatment advice, but as an educational and informational tool that is personalised to your genetic data. Beyond the genes covered here, there are around 200 genes which have been identified that also contribute to MS. Non-genetic factors such as Vitamin D also play a role in MS, and are explored in this report .

What is Multiple Sclerosis?

Multiple Sclerosis (MS) is a rare autoimmune condition which is caused by the body’s own immune system attacking its central nervous system .

It is characterized by a wide variety of symptoms including problems with vision, movement and speech .

The risk of developing MS is influenced by many factors including genetics. Several genes have been identified in influencing the development of MS, many of which regulate the immune system.

Which genes influence a person's possible development of Multiple Sclerosis?

The Human Leukocyte Antigen (HLA) is a family of MS related genes that make a group of proteins called the HLA complex which plays a role in helping immune cells communicate with each other. The HLA complex helps the immune system to differentiate between foreign attackers (e.g. bacteria or viruses) and the body's own tissues. In MS, the immune system is unable to distinguish between the body's own tissues and a foreign attacker due to a miscommunication between immune cells.

Different variations of HLA genes have been found to relate to the risk of developing MS. Two of those variations are HLA-DRB1 (rs3135388) and HLA-G (rs4959039). Allele rs3135388(T) in HLA-DRB1 has been associated with a 3 to 6-fold higher risk of developing MS.

SNP rs3135388

You have the variant TC at position rs3135388. You have about a 3 times higher risk, than the average person, of developing Multiple Sclerosis.

Allele rs4959039(G) in HLA-G has shown to be associated with around a 2-fold higher risk for developing MS.

SNP rs4959039

You have the variant AG at position rs4959039. You have about a 1.4 times higher risk, than the average person, of developing Multiple Sclerosis.

What environmental factors influence a person's chances of developing Multiple Sclerosis?

One of the environmental factors which has been linked to the development of MS is vitamin D deficiency. People with MS have lower levels of 25-hydroxyvitamin D3 (25-OHD3) in their bodies. Research suggests that increasing Vitamin D levels in people with a predisposition to developing MS may reduce risk of developing the condition.

In the kidney, skin and immune cells, 25-OHD3 is processed and activated by a gene called CYP27B1. This means that the final level of active vitamin D3 is dependent not just on Vitamin D levels, which is influenced by factors such as sun exposure and diet, but also genetic factors in the CYP27B1 gene.

Low levels of CYP27B1 will likely influence the available amount of active vitamin D3 present in the body. As a result, studies have shown that Individuals with allele rs703842 (T), which is correlated with lower levels of CYP27B1, are on average more likely to be affected by MS.

SNP rs703842

You have the variant TT at position rs703842. This variant is associated with an increased risk of developing Multiple Sclerosis.

What are T cells and what role do they play in developing Multiple Sclerosis?

The IL7RA gene produces a protein that participates in immune system response and in T cell (a type of immune cell) development. Some genetic variants in IL7RA result in decreased protein levels. It has been shown that carriers of the allele rs6897932 (C) produce less IL7RA, and people with allele rs6897932 (C;C) have about 2 fold higher risk for MS development. On the other hand, the (C;T) and (T;T) variants are associated with protection against MS.

SNP rs6897932

You have the variant CC at position rs6897932. This variant is associated with an 1.08 times higher risk, than the average person, of developing Multiple Sclerosis.

T Cells, mentioned previously, are an important part of our body's immune system and are involved in ‘adaptive immunity’, which includes a system for remembering past threats and responding to those threats when they occur again. MS, like many autoimmune diseases, is in part the result of T Cells not functioning correctly, and attacking the bodies own cells.

IL2RA produces a protein that is involved in T-Cell growth, and genetic variants in IL2RA are associated with MS risk. The rs2104286 (A) allele is associated with a higher risk of MS, while the rs2104286 (G;G) allele is associated with lower MS risk. One of the FDA-approved treatments for MS, daclizumab, works by blocking IL2RA.

In conclusion

There are around 200 genes which could influence a person’s development of Multiple Sclerosis, many of which regulate the immune system. Some genes may increase or decrease the risk of developing MS directly, whereas others may increase or decrease the risk of associated conditions such as vitamin D deficiency that can influence a person's likelihood of developing MS. However, genetics is just a small factor among many other factors (including environmental, immunologic and infectious factors) which influence a persons likelihood of developing MS.

Research into immunology, epidemiology, genetics and infectious agents is essential to increase our understanding of the causes of MS as well as helping to discover more effective treatments.

References

[1]National MS Society: What Causes MS?

[2]Mayo Clinic: Multiple Sclerosis

[3]Sano Genetics: Multiple Sclerosis

Glossary

[Environmental Factors]

Environmental factors are external influences that can affect an individual's health and wellbeing.

[Immune System]

The organs and processes of the body that provide resistance to infection and toxins.

[Immunological]

Relating to the structure and function of the immune system

[Infectious Agents]

Is generally used to describe and encompass any material that can cause an infection that can lead to a disease. There are four main classes of infectious agents: bacteria, viruses, fungi, and parasites.

[Protein]

Proteins are large, complex molecules that play many critical roles in the body.

[SNP]

SNP stands for 'single nucleotide polymorphism' and refers to regions of DNA that vary

Sano home

But even more DNA using  DNA from tellmegen.com

rs10492972       AG (or TC if reading the complementary DNA strand))                     G (or C) is the risk allele

KIF1B gene              conflicting reports; possible slight increased risk for multiple sclerosis

rs12722489     IL2RA gene    AG                   a slight increase in risk of developing multiple sclerosis      G is the risk allele

rs6498169        AG       KIAA0350 gene   1.14x risk of multiple sclerosis          A is the risk allele

rs10984447    AG        DBC1 gene        1.17x increased risk for multiple sclerosis    A is the risk allele

rs12044852   AC         CD58                  1.24X risk           C is the risk allele

rs12708716    AA       CLEC16A       1.6x risk of type-1 diabetes and other autoimmune diseases (such as MS)          A is the risk allele

rs4149584     GG        TNFRSF1A       normal risk           A is the risk allele

rs3135388     AG (or TC)      HLA-DRA          3x higher risk of multiple sclerosis                 A (or T) is the risk allele