Quinine. 11/15/2015

 I am shooting for 30mg, as a  daily dose to help control spasticity  in Multiple Sclerosis, as recommend by my Neurologist.

What is going on here is an acidic extraction. Quinine is an alkaloid, which is an alkaline compound derived from a plant. This reacts with an acid, in our case citric acid. A salt is formed, quinine citrate, which dissolves easily in water

The recipie below should get me close

Content Comparison by Cinchona species

Species Total Alkaloids (%) Quinine Content (%)

C. calisaya 3 - 7    0 - 4

C. pubescens 4.5 - 8.5.   1 - 3

  Used this.  C. officinalis 5 - 8    2 - 7.5

C. ledgeriana 5 -14    3 - 13

C. succirubra 6 - 16    4 - 14

So ask which varietal you are getting. The above is just a guide. Hope it is useful.

So knowing which varietal you are getting helps in knowing which are stronger etc.

The Most Popular Tonic Water Syrup Recipe Has Too Much Quinine

Let's take one of the most popular tonic syrup recipes, published by Jeffrey Morgenthaler: Basically, it's 6 cups of liquid to 1/4 cup of powdered cinchona bark, which is about 35 grams of cinchona. Extrapolate from that and we're talking about 35 grams of cinchona per 1.4 liters of end syrup, which is 25 grams per liter, and if it extracts fully, contributes 1.25 grams of quinine per liter, which equates to 1251 parts per million. That's 15 times the CFR standard.

If you use 3/4 of an ounce of that syrup in a Gin and Tonic, you're adding in 27.5 mg of quinine - more than double the amount of quinine in a commercial gin and tonic

Used 4 cup water, 10 allspice berries.   Made 3/4 liter bottle.

Simmered just over 20 minutes. 3/4 oz serving took. Brown murkey color. Left unfiltered.

• 4 cups water
• 1 cup chopped lemongrass (roughly one large stalk)
• ¼ cup powdered cinchona bark
• zest and juice of 1 orange
• zest and juice of 1 lemon
• zest and juice of 1 lime
• 1 tsp whole allspice berries
• ¼ cup citric acid
• ¼ tsp Kosher salt

1. Combine ingredients in a medium saucepan and bring to a boil over high heat.
2. Once mixture starts to boil, reduce heat to low, cover and simmer for 20 minutes.
3. Remove from heat and strain out solids using a strainer or chinois.
4. You'll need to fine-strain the mixture, as it still contains quite a bit of the cinchona bark.
5. You can use a coffee filter and wait for an hour or more, or do as I do and run the whole mixture through a French coffee press.
6. Once you're satisfied with the clarity of your mix, heat it back up on the stovetop or microwave, and then add ¾ cup of agave syrup to each cup of your hot mix.
7. Stir until combined, and store in the attractive bottle of your choice.
8. You now have a syrup that you can carbonate with seltzer water; I use my iSi soda siphon for some nicely-textured bubbles.
9. To assemble a gin and tonic, use ¾ ounce of syrup, 1½ ounces of gin and 2 ounces of soda water over ice.

http://www.onlybitters.com/only-bitters-cinchona-succirubra-milled-powder-500gm/

Only Bitters Cinchona Succirubra Milled Powder 18oz (500gm)

$28.99

CITRIC ACID  from internet

walmart

Jacquard Citric Acid, 1lb $8.99

cinchona and citric acid mail order from Herbal Advantage, Rogersville, MO.

http://www.jeffreymorgenthaler.com/2008/how-to-make-your-own-tonic-water/

Quinine is an alkaloid, which is an alkaline compound derived from a plant. This reacts with an acid, in our case citric acid. A salt is formed, quinine citrate, which dissolves easily in water.

4 cups water

1 cup chopped lemongrass (roughly one large stalk)

¼ cup powdered cinchona bark

zest and juice of 1 orange

zest and juice of 1 lemon

zest and juice of 1 lime

1 tsp whole allspice berries

¼ cup citric acid

¼ tsp Kosher salt

Combine ingredients in a medium saucepan and bring to a boil over high heat. Once mixture starts to boil, reduce heat to low, cover and simmer for 20 minutes

read his entire recipie

http://rain-tree.com/prepmethod.htm#.VrEWaN_TnGW

http://www.alcademics.com/2014/08/potential-dangers-of-homemade-tonic-water.html#comment-6a00e553b3da20883401a3fd43daf0970b

There's a federal standard for the use of quinine in carbonated beverages, specifically that it cannot exceed 83 parts per million in the final tonic water (21 CFR 172.575). Now, if you're working with commercial quinine sulphate or quinine hydrochloride, it's easy to calculate. Basically, that ends up being 2.48 mg of commercial quinine per ounce of tonic water.

So, let's expand this out: a typical gin and tonic is 1.5 oz of gin and 4.5 oz of tonic, 6 ounces total. That means we can expect 11.16mg of quinine in that beverage.

However, most producers of tonic syrups don't use quinine hydrochloride/quinine sulphate... and there's the rub.

Cinchona bark is approximately 5% quinine.

Let's take one of the most popular tonic syrup recipes, published by Jeffrey Morgenthaler: Basically, it's 6 cups of liquid to 1/4 cup of powdered cinchona bark, which is about 35 grams of cinchona. Extrapolate from that and we're talking about 35 grams of cinchona per 1.4 liters of end syrup, which is 25 grams per liter, and if it extracts fully, contributes 1.25 grams of quinine per liter, which equates to 1251 parts per million. That's 15 times the CFR standard.

If you use 3/4 of an ounce of that syrup in a Gin and Tonic, you're adding in 27.5 mg of quinine - more than double the amount of quinine in a commercial gin and tonic. 

Note: Does a syrup extract quinine fully from the cinchona? No - but it extracts faster from powdered cinchona versus cinchona chips or quills.

Note: Does a syrup that is sieved through a french press or a coffee filter have a high percentage of solids still in suspension? Yes - and any of the solids you swallow contribute the full amount of the quinine as your body digests the powder. 

. Hope it is useful. Species Total Alkaloids (%) Quinine Content (%)

C. calisaya 3 - 7 0 - 4

C. pubescens 4.5 - 8.5 1 - 3

C. officinalis 5 - 8 2 - 7.5

C. ledgeriana 5 -14 3 - 13

C. succirubra 6 - 16 4 - 14

So knowing which varietal you are getting helps in knowing which are stronger etc.

INGREDIENTS

3½ cups water¼ cup (1 ounce) chopped cinchona bark¼ cup citric acid3 limes, peeled zests only3 lemons, peeled zests only2 oranges, peeled zests only3 stalks lemongrass, chopped4 whole allspice berries3 whole cardamom pods1 tablespoon lavender¼ teaspoon kosher salt

Rich Simple Syrup

2 cups natural cane sugar1 cup water

You'll also need:

Lime wedgesSparkling water

INSTRUCTIONS

Combine all ingredients except rich simple syrup in a one-quart lidded glass jar. Shake to combine. Refrigerate 72 hours, shaking occasionally, at least once per day.Make rich simple syrup: dissolve 2 cups sugar in 1 cup water over medium heat until sugar is completely dissolved. Allow to cool. Transfer to a container and refrigerate.After 72 hours, strain tonic mixture into a large glass pitcher. Strain tonic a second time, using a coffee filter or very fine cheesecloth.Whisk simple syrup into tonic until thoroughly combined.Pour tonic syrup through a funnel into storage bottles and store in the refrigerator.

For the Ultimate Gin & Tonic

Fill a highball glass with ice. Add 1 tablespoon tonic syrup, 2 ounces gin, and 2 ounces sparkling water. Stir to combine. Serve with a lime wedge (about ⅙ of a fresh lime). To drink: squeeze the lime wedge into the drink, then drop it in. Enjoy!

Makes about 4½ cups

Eyes and MS

Know I've covered this before, but my prior optometrist has put up a link, that I don't want to loose. May do others good watching short videos.

https://youtu.be/oaElHt_kSFE

I am using AI to write most of this post.  Yes I have experienced this a few times, caught by Dr Corn well also

 My old ophthalmologist moved to the East, but he put up a great website of videos t watch, that clearly explains eye issues

https://www.youtube.com/@visionrefocused/about

 Multiple sclerosis (MS) is a chronic neurological disorder that affects the central nervous system, including the brain and spinal cord. It can lead to a wide range of symptoms and complications, and the eyes are commonly affected in individuals with MS.

Optic neuritis is one of the most common eye-related symptoms experienced by people with MS. It occurs when the optic nerve, which transmits visual information from the eye to the brain, becomes inflamed. Optic neuritis can cause various visual disturbances, such as blurred vision, loss of color vision, blind spots, and pain with eye movement. Some individuals may also experience temporary vision loss.

Optic neuritis is a condition characterized by inflammation of the optic nerve, which is responsible for transmitting visual information from the eye to the brain. It can cause various symptoms, including vision loss, blurred vision, eye pain, and changes in color vision.

Optic neuritis is often associated with multiple sclerosis (MS), an autoimmune disease that affects the central nervous system. In fact, it is one of the most common initial symptoms of MS. When optic neuritis is linked to MS, it is referred to as "optic neuritis in the context of multiple sclerosis" or "MS-associated optic neuritis."

MS-associated optic neuritis typically affects one eye, causing acute vision loss or visual disturbances. The inflammation in the optic nerve is thought to be triggered by an abnormal immune response, which leads to the demyelination (damage to the protective covering of nerve fibers) in the optic nerve.

Diagnosis of MS-associated optic neuritis involves a thorough eye examination, which may include visual acuity tests, color vision tests, visual field tests, and an examination of the back of the eye using an ophthalmoscope. Additional tests, such as optical coherence tomography (OCT) or magnetic resonance imaging (MRI), may be used to assess the extent of nerve damage and look for other signs of MS.

Treatment for optic neuritis aims to reduce inflammation and speed up the recovery of vision. High-dose intravenous corticosteroids, such as methylprednisolone, are often prescribed to reduce inflammation. Some individuals may also benefit from oral corticosteroids. Over time, vision typically improves, although it may not fully return to normal.

It is important to note that the presence of optic neuritis does not necessarily mean a person will develop MS. However, having optic neuritis does increase the risk of developing MS in the future. Therefore, individuals with optic neuritis may undergo further evaluation to assess the likelihood of developing MS and to determine if any additional treatment or monitoring is needed.

If you suspect you have optic neuritis or have been diagnosed with it, it is crucial to consult with a healthcare professional, such as an ophthalmologist or a neurologist, who can provide a proper evaluation, diagnosis, and appropriate treatment recommendations based on your specific situation.

Another eye-related symptom associated with MS is double vision (diplopia). This occurs when there is a disruption in the coordination of eye movement, leading to overlapping or duplicated images. Double vision can occur due to damage to the nerves controlling eye movements in MS.

Double vision, also known as diplopia, can be a symptom of multiple sclerosis (MS). MS is an autoimmune disease that affects the central nervous system, including the brain and spinal cord. It occurs when the immune system mistakenly attacks the protective covering of nerve fibers, disrupting the normal communication between the brain and other parts of the body.

In MS, double vision can arise from several causes, including damage to the nerves that control eye movement or coordination. This can result in misalignment of the eyes, leading to the perception of two overlapping images. Double vision associated with MS can be temporary or persistent and may affect one or both eyes.

The occurrence of double vision in MS can vary in severity and may be exacerbated by fatigue, heat, or prolonged use of the eyes. It may also fluctuate over time, appearing and disappearing intermittently.

If you are experiencing double vision or any visual disturbances, it is important to consult with a healthcare professional, such as a neurologist or ophthalmologist, who can assess your symptoms and determine the appropriate course of action. They may perform a comprehensive evaluation, including a detailed medical history, neurological examination, and possibly additional tests such as MRI or visual field testing to assess the extent of nerve damage and identify any other underlying causes.

Treatment for double vision in MS aims to address the underlying condition and alleviate symptoms. This may involve disease-modifying therapies to manage the progression of MS, medications to manage specific symptoms, such as muscle spasms or fatigue, or referral to an eye specialist for corrective measures such as prism glasses, eye exercises, or, in rare cases, surgical interventions.

It's worth noting that double vision can have various causes, and while it can be associated with MS, it does not automatically indicate an MS diagnosis. Therefore, proper medical evaluation is necessary to determine the cause of your specific symptoms and provide appropriate treatment options.

Use of AI, or known media trusted sites to look up conditions, so your Drs know is important.

It's important to note that eye problems in MS can vary widely in severity and duration. While some individuals may experience temporary and mild symptoms, others may have more persistent or severe visual impairment. It's recommended that individuals with MS who experience any changes in their vision or eye-related symptoms consult their healthcare provider. They may refer them to an ophthalmologist or neurologist for further evaluation and management of their eye symptoms.

It's worth mentioning that MS is a complex condition, and its effects on the eyes can vary from person to person. It's always best to consult with a medical professional for personalized advice and guidance based on your specific situation.

Mushrooms and Multiple Scletosis good? Bad?

 

Yes, most of this post is being written with Artificial Intelligence (AI)

I will add, watch the supplier of Mushrooms closely, as this FAD, takes over, making some billions off of ingredients that are not extracted properly for health. You can buy these in pills, powder, fruiting bodies, the roots, but extraction is a key element of what they do.

My Neurologist has me trying, A Test subject.

 Reishi mushroom, also known as Ganoderma lucidum, is a medicinal mushroom that has been used for centuries in traditional Chinese medicine. Here's some information about reishi mushrooms:

Immune System Support: Reishi mushrooms are believed to have immunomodulating effects, meaning they can help regulate and support the immune system. They contain various bioactive compounds, such as polysaccharides and triterpenes, which may enhance the activity of immune cells and promote overall immune function.

Antioxidant Properties: Reishi mushrooms are rich in antioxidants, which help protect the body against oxidative stress caused by free radicals. The antioxidants found in reishi mushrooms, such as triterpenes and phenolic compounds, may have beneficial effects on cellular health and help reduce inflammation.

Stress Reduction and Sleep Support: Reishi mushrooms have been traditionally used to promote relaxation, reduce stress, and support healthy sleep patterns. Some research suggests that the bioactive compounds in reishi mushrooms, such as triterpenes and polysaccharides, may have calming and adaptogenic properties that can help manage stress and improve sleep quality.

Potential Anti-Cancer Effects: Some studies have explored the potential anti-cancer properties of reishi mushrooms. The bioactive compounds in reishi mushrooms have been investigated for their ability to inhibit tumor growth, enhance immune response against cancer cells, and potentially have direct anti-cancer effects. However, more research is needed to fully understand and confirm these effects.

Reishi mushrooms are available in various forms, including dried mushrooms, extracts, and capsules. It's important to note that while reishi mushrooms are generally considered safe for most people, they may interact with certain medications or have potential side effects. It's always recommended to consult with a healthcare professional before adding any new supplements or mushrooms to your routine, especially if you have any underlying health conditions or are taking medications.

Additionally, it's worth mentioning that while reishi mushrooms may have potential health benefits, they should not be considered a substitute for medical treatment. If you have specific health concerns, it's important to seek professional medical advice for a comprehensive evaluation and appropriate management

Lion's mane mushrooms (Hericium erinaceus) have gained popularity in recent years for their potential health benefits. Here's some information about lion's mane mushrooms:

Nerve Regeneration: Lion's mane mushrooms are known for their potential to promote nerve growth and regeneration. They contain compounds called erinacines and hericenones, which have been studied for their ability to stimulate the production of nerve growth factors. These compounds may have potential applications in supporting nerve health and potentially aiding in the management of neurodegenerative conditions. However, further research is needed to establish the extent of their benefits and their specific mechanisms of action.

Cognitive Function: Some studies have suggested that lion's mane mushrooms may have cognitive benefits. These mushrooms have been investigated for their potential to enhance memory and improve cognitive function. The exact mechanisms by which lion's mane mushrooms may exert these effects are still being explored, but they are thought to involve the stimulation of nerve growth factors and the promotion of neuroplasticity.

Mood and Mental Health: Preliminary studies have indicated that lion's mane mushrooms may have mood-boosting effects and potential applications in mental health. These mushrooms have been suggested to have anxiolytic (anxiety-reducing) and antidepressant-like effects in animal models. However, more research is needed to confirm these findings and understand the mechanisms involved.

Immune Function: Lion's mane mushrooms may also have immune-modulating properties. Some studies have shown that they can enhance the activity of immune cells, such as natural killer cells and macrophages, which play important roles in immune defense.

It's important to note that while lion's mane mushrooms show promise, much of the research has been conducted in animal models or in vitro (in a laboratory setting), and human studies are still limited. Therefore, further research is needed to fully understand the potential benefits and determine appropriate dosages for specific health conditions.

If you are considering adding lion's mane mushrooms to your diet or taking them as a supplement, it's always best to consult with a healthcare professional or a registered dietitian. They can provide guidance based on your individual health needs and help ensure the safe and appropriate use of supplements.

This Blend has Turkey Tail Mushroom in it.

Turkey tail mushroom, scientifically known as Trametes versicolor, is a type of medicinal mushroom that is commonly used in traditional Chinese and Japanese medicine. Here's some information about turkey tail mushrooms:

Immune System Support: Turkey tail mushrooms are believed to have immunomodulatory effects, meaning they can help regulate and support the immune system. They contain compounds like polysaccharopeptides (PSP) and polysaccharides, which may stimulate immune cell activity and enhance the body's defense against pathogens.

Antioxidant Properties: Turkey tail mushrooms are rich in antioxidants, such as phenols and flavonoids, which help protect the body against oxidative stress and damage caused by free radicals. Antioxidants can support overall health and may have potential benefits for various conditions.

Gut Health: The gut microbiome plays a vital role in overall health, and turkey tail mushrooms may have positive effects on gut health. Some research suggests that the bioactive compounds in turkey tail mushrooms can promote the growth of beneficial gut bacteria, which may help improve digestion and support a healthy gut environment.

Cancer Support: Turkey tail mushrooms have been studied for their potential anti-cancer properties. The polysaccharide compounds in turkey tail mushrooms, such as PSK (polysaccharide-K) and PSP, have been investigated for their ability to enhance immune function, inhibit tumor growth, and potentially improve outcomes in certain types of cancer. However, it's important to note that more research is needed to fully understand their effects and determine their specific applications.

Turkey tail mushrooms are available in various forms, including dried mushrooms, extracts, and capsules. It's important to source them from reputable suppliers or consult with a healthcare professional or herbalist before using them as a supplement. They are generally considered safe for most individuals, but they may interact with certain medications or have potential side effects.

As with any health-related decision, it's advisable to consult with a healthcare professional before incorporating new supplements or mushrooms into your routine, especially if you have underlying health conditions or are taking medications. They can provide personalized guidance based on your specific health needs.

Of course, thanks for reading.

Know its been a while since posting, but will catch everyone up one day.

JoeY

Vitamin B retake Again 2016 or 2023 ground hog day

 The Year is 2016. Vitamin B

Photo by Wikipedia

           Lets Time Travel some

Vitamin B Protocol was added to my daily regime in 2016 by a excellent Dr. This was taking individual vitamins Bs, not the multivitamin, as that did not have the amount of each vitamin desired, or needed.

This went on for six months .  

Now lets talk about the Ground hog movie..haha

The Year 2023, I am on the Same Vitamin B regime. Forgot I had done this in 2016.

 November 2022 my B12 was found to low. Neurologist wants it above 800, so assume thus All Bs are low.  So now Six months of loading, then off for 2-3 months to be retested, according to the protocol.

I am taking over the counter Bs, in different strengths. All water soluble. My GI said, A expensive experiment, as you pee out any excess.

Vitamin b7 was omitted, as is also known as biotin, and may cause endocrine test to give faulty results.  I was on high doses of Biotin, following a Trial with the real Biotin measured out on a Scale. Weird White Powder. I did get up there using high amounts, followed by a Neurologist. But the outcomes of the Study did not work.

But this time, with more knowledge. I have the H63D double gene, that gave me iron overload in 2017. 17 phlebotomy left me iron deficient for three years. No new phlebotomy needed.  But the Be being added may show a hiccup in next blood test? Read Wikipedia link below.

Several B vitamins aid in the sleep process. Vitamins B1 and B2 not only turn food into energy, but also produce melatonin, the sleep hormone. The production of melatonin shows that these vitamins encourage sleep. Taking a thiamine (vitamin B1) supplement can help you sleep better throughout the night, which will allow you to wake up feeling refreshed. To avoid deficiencies, add vegetables, eggs, and meat to your diet.

Vitamin B6 helps with your thinking ability and supports immune health. Because it aids cognitive function, it is no surprise that vitamin B6 enables you to remember your dreams. It also works to produce the two important hormones – serotonin and melatonin. Whereas melatonin makes you sleepy, serotonin stabilizes your mood. When these hormones are out of whack, your ability to sleep is negatively impacted. 

The combination of serotonin and melatonin produces a relationship between lack of sleep and depression. While not everyone who is depressed has sleep problems, a large percentage of these people suffer from insomnia. Many others with depression sleep too much, a condition called hypersomnia.

Some foods that are rich in vitamin B6 are cheese, fish, bananas and whole grains. A note to make about vitamin B6 is that too much of this vitamin can be toxic. Before starting a supplement, in addition to changing your diet, it’s best to talk to your doctor to ensure your level doesn’t get too high.

Vitamin B12 helps your body produce red blood cells and supports brain and cardiovascular functions. As far as sleep is concerned, it appears that vitamin B12 helps to regulate your circadian rhythm. However, studies show conflicting results about sleep. Some studies revealed that a deficiency led to insomnia, whereas other research showed that high levels were related to interrupted sleep patterns. Keeping your vitamin B12 level within a normal range will have the best outcome for your ability to sleep. To ensure you’re getting enough of this vitamin in your diet, eat shellfish, dairy and eggs.

https://www.activeiron.com/blog/best-time-to-take-vitamins/

What is each B Vitamin good for?

Vitamin B-1 is known as Thiamin. It plays a crucial role in breaking down carbs and protein. Good sources include peanuts, black beans, and grain products. Good sources: Whole or fortified grain products, pork, peanuts, and black beans.

Vitamin B-3 is also called Niacin. Found in peanuts, fish, brown rice, and whole grains.

Vitamin B-6 is involved in a vast amount of metabolic pathways – it’s essential for the optimal breakdown of food (and particularly carbohydrates) from big nutrients into small units the body can use. Good sources include bananas, tuna, chickpeas, and pistachios.

Vitamin B-9 is called Folate, and it’s essential to the production of red blood cells. It’s one of the building blocks of DNA and RNA. Good sources include avocados, leafy greens, broccoli, green peas, and more.

Vitamin B-12 is only found in animal products. Vitamin B-12 is crucial to the normal functioning of the nervous system. It helps to create and regulate RNA, and it’s also involved in the formation of red blood cells. The best time to take vitamin B-12 is in the morning similar to all B vitamins.

https://www.medicalnewstoday.com/articles/319556#is-timing-important-for-vitamins

When to take B vitamins

People tend to take B vitamins to boost energy and reduce stress.

There are eight different types of B vitamins, each of which has a separate function for the body. The types of B vitamins are:

thiamin Vitamin B1 or thiamin is essential for glucose metabolism and nerve, muscle, and heart function.

riboflavin B2 Vitamin B2 helps break down proteins, fats, and carbohydrates. It plays a vital role in maintaining the body’s energy supply.

Riboflavin helps convert carbohydrates into adenosine triphosphate (ATP). The human body produces ATP from food, and ATP produces energy as the body requires it. The compound ATP is vital for storing energy in muscles.

Along with vitamin A, vitamin B is essential for:

vitamin B-6.  recent research indicates that vitamin B-6 may potentially interfere with sleepTrusted Source and induce vivid dreams. 

niacin

biotin

vitamin B-12

folic acid or Folate is important for a range of functions in the body.

It helps the body make healthy new red blood cells, for example. Red blood cells carry oxygen throughout the body. If the body does not make enough of these, a person can develop anemia, leading to fatigue, weakness, and a pale complexion.

Without enough folate, a person can also develop a type of anemia called folate deficiency anemia.

Folate is also important for the synthesis and repair of DNA and other genetic material, and it is necessary for cells to divide

From BrainMD.Com

https://brainmd.com/blog/folic-acid-vs-folate-everything-you-need-to-know/#:~:text=Methylfolate%20is%20the%20folate%20form,absorb%20it%20into%20the%20blood. 

WHAT’S THE DIFFERENCE BETWEEN FOLATE, FOLIC ACID, AND METHYLFOLATE?

Many foods are being “fortified” with folic acid (FA) to help consumers maintain good nutritional folate status. Also, dietary supplements that include folate typically provide it as FA. Yet this substance is a manufactured folate that is known to be poorly utilized by the body’s folate enzyme system. The body has to use an enzyme to make FA usable, and this enzyme’s conversion capacity is limited. Consequently, many people have unconverted FA in their bloodstream, which studies have linked to negative health effects.

Methylfolate is the folate form most naturally preferred by the body, so much so that the intestinal lining has “transport proteins” that bind to it and selectively absorb it into the blood. Similar proteins also move MF from the circulation into the brain tissue. But MF utilization can be blocked by the FA coming from fortified foods or poorly formulated dietary supplements. Folic acid is not just poorly effective — it actually interferes with the enzymes that are tasked with using MF and the other folates coming from our foods. Folic acid consumption is a serious health issue.

Bottom line: always choose supplements with methylfolate instead of folic acid.

Now the MTHFR Gene people think plays how items are absorbed. Yes an no?

The below is a great blog that talks about this.

About Methylfolate

https://anabundantlife.com.au/methylfolate-feel-bad/

Have you ever wondered how many b vitamins there are?

https://en.m.wikipedia.org/wiki/B_vitamins

This is one of my favorite, as describes in detail all the B vitamins. I will let you look at this link on your research.

Vitamin D, has been talked about in prior blogs. Perhaps the best defense in MS, and keeping things in control. However, be followed by a endocrinologist, as D can pull calcium from bones, put into blood stream, cause kidney stones and more at high dose.

Vitamin K-4 will help keep this from happening.

A Experiment for Scientist in the making.

Now what happened to all my post for the last year and half?  Made them, just not right time for posting them, as  under investigation by experts experts, Alarming, perhaps, but so is MS, or anything.  More info doesn't change anything, just gives different perspectives.

Ok, enough of ground hog day repeating in another year,

Take time to listen to the birds!

Thanks for reading. Feel free to comment, as have not covered everything needed

JoeY

Vitamin B and what is effected in MS with DNA

 

Vitamin B

Image from Wikipedia

B1 is used for Metabolism.  According to Wikipedia, "Thiamine, also known as thiamin and vitamin B₁, is a vitamin, an essential micronutrient, that cannot be made in the body.^[3][4] It is found in food and commercially synthesized to be a dietary supplement or medication.^[1][5] Phosphorylated forms of thiamine are required for some metabolic reactions, including the breakdown of glucose and amino acids.^[1] "

B2,  Riboflavin, also known as vitamin B2, is a vitamin found in food and sold as a dietary supplement. It is essential to the formation of two major coenzymes...f!avin mononucleotide and flavin adenine dinucleotide  What is riboflavin and what does it do? Riboflavin (also called vitamin B2) is important for the growth, development, and function of the cells in your body. It also helps turn the food you eat into the energy you need.

B3 Niacin. It can treat high cholesterol and triglyceride levels as well as niacin deficiency. It can also reduce the risk of heart attack and slow narrowing of the arteries.

Overview. Niacin is a B vitamin that's made and used by your body to turn food into energy. It helps keep your nervous system, digestive system and skin healthy.

 key difference between vitamin B3 and B12 is that vitamin B3 is important in controlling cholesterol and triglyceride levels in our blood, whereas vitamin B12 is important as a cofactor in DNA synthesis for both fatty acid and amino acid metabolism.Niacin, also known as vitamin B3, is an important nutrient. In fact, every part of your body needs it to function properly. As a supplement, niacin may help lower cholesterol, ease arthritis, and boost brain function, among other benefits.

May reduce blood pressure. One role of niacin is to release prostaglandins, or chemicals that help your blood vessels widen — improving blood flow and reducing blood pressure. For this reason, niacin may play a role in the prevention or treatment of high blood pressure 

Vitamin B3 is a member of the vitamin family, which includes three forms of vitamers as nicotinamide, niacin, and nicotinamide riboside. Vitamin B12 is a type of vitamin involved in metabolism in our body.

what-is-the-difference-between-niacin-niacinamide/

B5. Pantothenic acid, also called vitamin B₅ is a water-soluble B vitamin and therefore an essential nutrient. All animals require pantothenic acid in order to synthesize coenzyme A – essential for fatty acid metabolism – as well as to, in general, synthesize and metabolize proteins, carbohydrates, and fats     what is B5 vitamins good for? In addition to playing a role in the breakdown of fats and carbohydrates for energy, vitamin B5 is critical to the manufacture of red blood cells, as well as sex and stress-related hormones produced in the adrenal glands, small glands that sit atop the kidneys.

B6. Vitamin B-6 pyridoxine is important for normal brain development and for keeping the nervous system and immune system healthy. Food sources of vitamin B-6 include poultry, fish, potatoes, chickpeas, bananas and fortified cereals Vitamin B6 is a vitamin that benefits the central nervous system and metabolism. Its roles include turning food into energy and helping to create neurotransmitters, such as serotonin and dopamine.Vitamin B6 is one of eight B vitamins. This group of vitamins is important for proper cell function. They help with metabolism, creating blood cells, and keeping cells healthy.  also known as pyridoxine, vitamin B6 is a water-soluble vitamin, which means it dissolves in water. The body does not store vitamin B6 and releases any excess in urine, so people need to get enough vitamin B6 every day.

B9  Folic Acid.  aids in the production of DNA and RNA, the body's genetic material, and is especially important when cells and tissues are growing rapidly, such as in infancy, adolescence, and pregnancy. Folic acid also works closely with vitamin B12 to help make red blood cells and help iron work properly in the body.

Vitamin B9, also called folate or folic acid, is one of 8 B vitamins. All B vitamins help the body convert food (carbohydrates) into fuel (glucose), which is used to produce energy.

What happens when you lack B9? Vitamin B9 deficiency can lead to anaemia and might increase your risk of heart disease. It's also really important during early pregnancy for a developing baby. Signs of deficiency include tiredness, weakness, shortness of breath, heart palpitations, and difficulty concentrating.

When you have anemia, your blood can't bring enough oxygen to all your tissues and organs. Without enough oxygen, your body can't work as well as it should. Low levels of folic acid can cause megaloblastic anemia. With this condition, red blood cells are larger than normal. It works wit B12

Folic acid helps make healthy red blood cells, which carry oxygen around the body. If you do not have enough folic acid, your body can make abnormally large red blood cells that do not work properly. This causes folate deficiency anaemia, which can cause tiredness and other symptoms.

What is Methyl Folate?
Methylfolate, sometimes known as L Methylfolate or 5-MTHF, is the active, more bioavailable form of the essential B-Vitamin Folic Acid. In order for the body to use Folic Acid, it must first be converted to Methyl Folate. 

Folic acid and folate can be cheap, but methylfolate tends to be the most effective option when it comes to treating the unique needs of MTHFR and giving the body an enzyme it can directly act upon. L-methylfolate (chemically (6S)-5-Methyltetrahydrofolate) is the most pure, active form of methylfolate you can buy.

B12 Vitamin B₁₂, also known as cobalamin, is a water-soluble vitamin involved in metabolism. It is one of eight B vitamins. It is required by animals, which use it as a cofactor in DNA synthesis, in both fatty acid and amino acid metabolism. Wikipedia. 

Vitamin B12 is a nutrient that helps keep your body's blood and nerve cells healthy and helps make DNA, the genetic material in all of your cells. Vitamin B12 also helps prevent megaloblastic anemia, a blood condition that makes people tired and weak

Methylcobalamin. Methylcobalamin is the most bio-available type of Vitamin B12 which means the body absorbs it more easily. Naturally occurring, it is found in animal-based foods such as meat, fish, milk and eggs

People sometimes ask which of the two supplements is better – the artificial (cyanocobalamin) or naturally occurring (methylcobalamin). Studies have shown that cyanocobalamin is known to absorb slightly better within the body while methylcobalamin is considered to retain better and for longer.Aug 23, 2022.

t, and eat thru your gut.ry

DNA. mthfre Gene

The MTHFR gene codes for a key 

enzyme in folate metabolism

I just so happen to have this Gene, and wrote about it before I found out I was Vitamin Deficiency of B12.  I am below 200. Neurologist wants me above 800. I went thru my entire team, to ensure the individual combinations might be of help.  It may be a double edge sword though, as thick blood cells become problematic.

Methylenetetrahydrofolate reductase deficiency is the most common genetic cause of elevated serum levels of homocysteine (hyperhomocysteinemia). It is caused by genetic defects in MTHFR, which is an important enzyme in the methyl cycle.^[1]

Thanks for reading.

Hope this will let you question each vitamin, and amount used, and why.

I did not go into full details, but a starting point.

Energy Drinks full of only certain B vitamins, that may not be the best to try

My Dr also agreed, that if I'm deficient in b12, that I am deficient in other B Vitamins.

I am not a Doctor, so check with yours before taking any supplements. Some may interfere with other meds.

A few of ones to start with. Vitamin B7, or Biotin, i stayed away from, as it effects blood test

B1 250mg metabolism

B2 as Riboflavin 100mg

B3 as Niacin 500 mg

B5 as Pantothenic Acid 500 Mg

B6 100 mg Metabolism support

B9 800 Mcg as folic Acid

B9 Methylfolate

B12 as Methylcobalamin 2000 mcg

B12 as cyanocobalamin 3000