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Sunday, October 23, 2022

Lyons Mane Mushroom and Effects With Multiple Sclerosis



Lyons Mane Mushroom and Effects with Multiple Sclerosis

 What is there to say about a mushroom that looks like a fluffy white lion (how it got its name)?

Quite a bit, as it turns out.

Lion’s mane (Hericium erinaceus) has been both a culinary mushroom and medicine throughout history. It has a delicate flavor and powerful health-promoting compounds when it comes to traditional use. It was (and still is) an important medicine in Traditional Chinese Medicine (TCM).

But, more notably, its benefits have come under the scrutiny and excitement of scientific research— all because what it is capable of doing is so noteworthy that it deserves its own spotlight, and possibly even its own exploration into potential as medicine in the mainstream.



WHAT LION’S MANE CAN DO FOR HEALTH

So, what exactly is this alien-looking mushroom capable of? A lot, according to both tradition and science.

The following are the most notable benefits for health that can be found in lion’s mane. Many of these bridge any gap that can be found between the mushroom’s original folk use and the modern science that supports it.

NEUROPROTECTOR

Lion’s mane’s capabilities as a powerful neuroprotector are what truly lay the foundation of all the outstanding things it can do.

“Neuroprotector” (also called “neurotrophic”) means that something protects the nerves and neurons, and possibly even stimulate better healing and growth in the entire nervous system. slots malaysia

A 2013 review indeed termed lion’s mane a neuroprotective botanical owing to all the evidence of its effects.

What this means is that lion’s mane has the potential to protect, heal, and support anything related to the nervous system or what could affect it, including functions, health, damage, and more.

IMPROVE MEMORY

From neuroprotective abilities, many other benefits can branch out—and one of these is improving memory naturally.

Memory is innately tied to how neurons and nerves function in the brain.

If lion’s mane has the potential to protect these, then it can improve lots of different functions, not excluding memory.

Studies even show this is possible. In one study, test subjects were given extracts of the mushroom. These subjects demonstrated reduced experiences with short-term memory problems.

This means that, when used every day, lion’s mane might improve memory.

BOOST COGNITION AND FOCUS

Just as lion’s mane could boost memory, it could also improve cognition and focus. Meaning: it enhances the way the brain works, learns, and what it absorbs.

This means less distraction, slow thinking, and even mental fatigue.

That’s right, lion’s mane might help brain fog in the books. The same study showing how the mushroom affected memory also found that overall cognitive function benefitted from the use of the fungus.

It might just be the perfect supplement if getting distracted, forgetting those keys, and struggling with remembering important info at meetings sounds familiar.

REDUCE THE RISK OF NEUROLOGICAL DISEASES

Lots more besides memory struggles and cognitive issues could be helped by the likes of lion’s mane. For one, lion’s mane could actually help with neurological disorders for which each of these are just symptoms.

Most distinctively, studies show lion’s mane may help with Alzheimer’s and dementia.

After all, each has memory problems and cognitive dysfunction as trademark symptoms of their respective diseases. Studies are especially favorable of lion’s mane’s potential with Alzheimer’s, which studies show has strong indicators of being a great therapy for the neurological illness, pending more quality research.

PROTECT AGAINST STROKE

When science dubs lion’s mane a neuroprotector, this means it doesn’t just protect function and health—but against damage, too.

As a neuroprotector compared to other studied natural neuroprotectors and nootropics, lion’s mane reigns as king.

Its effects include protecting against powerful damage, even that resulting from a stroke. Studies even show that lion’s mane may help ameliorate the damage caused by strokes, too.

It certainly isn’t backed by enough research to be passed off as a stroke medicine or therapy quite yet. But what science has shown definitely opens up promising doors to the idea.


PROTECT AGAINST CONCUSSIONS AND BRAIN DAMAGE

Brain damage caused by a stroke can be similar to that caused by trauma, injury, or collision. As such, lion’s mane could have a hand in helping heal damage from concussions or other brain damage.

Damage is known as “ischemia injury” is the biggest concern following events like strokes or concussions.

The same study showing lion’s mane’s benefits for stroke-caused ischemia injury could thus apply to concussions. As a neuroprotective, it can specifically assist with guarding the brain, nerves, and tissues from damage due to lack of oxygen, blood clots, and more, research shows.

IMPROVE ANXIETY

Experiencing anxiety can feel emotional and spiritual, though it’s most definitely a mental health and nervous system problem.

Because it’s tied to nerves and neurons, however, anxiety could benefit from a neuroprotector like lion’s mane.

One study showed that lion’s mane extract for issues with anxiety could suppress some of its most troublesome symptoms, including irritation, concentration issues, heart palpitations, and more often not the anxiety itself.

What’s more, lion’s mane performed better for these symptoms compared to a placebo. It could mean great holistic support for anxiety and anxiety disorders, though more studies are needed.

HELP DEPRESSION

Even better yet, this healing mushroom oddity could play a role in helping or supporting depression (and possibly general stress, too).

The same study that showed benefits to people experiencing anxiety also showed perks for depression sufferers.

Once again, there were greater benefits felt from taking lion’s mane extract for depression compared to a placebo. Researchers concluded that lion’s mane should be investigated as a depression therapy, but that more studies would be needed before assuming it as an anti-depressant.

As with anxiety though, if lion’s mane protects the nerves, then it most likely helps depression.

WORKS LIKE AN ANTIOXIDANT

All of lion’s mane’s neuroprotective benefits make it quite unique. Science could easily regard the mushroom as one of the most well-researched and powerful neuroprotectors in the world today.

But in other ways, lion’s mane’s benefits could be more ordinary.

As a matter of fact, lion’s mane is shown to be a simple antioxidant: not that much different from nutritious antioxidant-rich foods or supplements like dark berries, cacao, or grape seed.

Research shows evidence confirming this too. In one study, lion’s mane extract showed very powerful antioxidant powers, some strong enough to protect major organs.

BOOSTS THE IMMUNE SYSTEM

One overlooked the power of antioxidants is that they can help naturally boost immunity.

Antioxidants do their part by fighting free radicals. These can cause inflammation and disease in the body, but can also impair immunity.

Lion’s mane boosts immunity by relieving chronic inflammation as an antioxidant.

Furthermore, polysaccharides—microscopic healing compounds—extracted from lion’s mane mushroom also showed their own unique characteristics in an interesting study. This research showed that the bizarre-looking fungus might not just enhance immunity blindly, but it could also modulate it so that it expressed itself in the healthiest way possible.

In the long run, this could also make lion’s mane useful and supportive of autoimmune disorders.

PROTECT THE LIVER

2012’s study on lion’s mane not only found that it had evidence of being a strong antioxidant, but that it could also be a great support for liver health.

In fact, the study particularly tested the mushroom’s antioxidant benefits on the liver organ itself. In the study, there appeared to be a formidable affinity between the lion’s mane mushroom extract and damaged or threatened tissues of the liver.

For this reason, one could call lion’s mane a liver protector.

More excitingly, it could also properly be called a “detox” supporter, since it appears to help the most important detox organ in the body: the liver.

GREAT FOR DIGESTIVE HEALTH

Beyond the liver—which can sometimes be called a major player of the digestive system—lion’s mane may have perks in store for all other players and organs in the digestive tract and system as well.

This is owed to an in vitro study of the mushroom’s gastroprotective effects.

In this fascinating study, extracts of lion’s mane showed protection of gastrointestinal tissues, including symptoms of certain disorders and even ulcers. It may very well be that these effects are owed to its antioxidant and immune-boosting effects on digestive tissues all combined.

REDUCE THE RISK OF CANCER

This strange yet exciting mushroom could be one’s ultimate botanical ally against one of the most feared diseases on the planet: cancer.

As a general antioxidant to start, lion’s mane may reduce the risk of any type of cancer that could be started by free radicals, and if taken every day.

Studies, on the other hand, have shown a specific affinity between the mushroom and gastrointestinal cancers. More specifically, lion’s mane has demonstrated potent effects against liver, rectal, and gastric cancers, though more studies are needed before referring to it or treating it like a cancer remedy.

EXPERIENCE LION’S MANE

Lion’s mane is one of the most widely-studied medicinal mushrooms and agreeably most powerful nootropics and neuroprotectors.  

These can be bought also at Primalherb.com

Information above supplied by Primal Herb for the Search of Lions Main Mushrooms, and studies website material is their material


Thank you for reading

JoeY



Friday, October 21, 2022

MTHFRE GENE

 MTHFRE GENE




The MTHFR gene codes for a key 

enzyme in folate metabolism. 

A large number of studies have

The associated the presence of 

common variants in the C677T and 

A1298C populations

 with a decreased folate metabolic capacity that could be related to several clinical conditions.

The MTHFR gene encodes for the enzyme methylene tetrahydrofolate reductase which plays

 a key role in folate and homocysteine metabolism by catalyzing the conversion of dietary

 ingested folate (vitamin B9) into the main circulating form of folate which is used in the 

conversion pathway of homocysteine to methionine. Methionine is an essential amino acid,

 not only for the constitution of the body's proteins, but also for DNA methylation and regulation 

of gene expression. In this sense, changes in the MTHFR gene sequence can lead to deficiency

 of this enzyme, and with this, to alterations in the folate conversion cycle and in the generation

 of methionine from homocysteine, which can lead to low levels of folate in blood and elevated 

levels of homocysteine in blood and urine (homocystinuria).

Variants in the MTHFR gene C677T and A1298C are two of the most common polymorphisms

 in the general population. Approximately 60-70% of individuals will have at least one of these 

variants, 8.5% will be homozygous (two copies) for one of them, and 2.25% will be compound 

heterozygous carriers (one copy of each variant). Both variants have been associated with

 reduced MTHFR enzyme activity, and reduced efficiency in folic acid processing. The C677T

 change decreases the affinity of MTHFR and its cofactor, which favors thermolability and 

decreasesn enzyme activity, whereas A12958C directly decreases enzyme activity. Hence,

 these variants have been associated with a variety of conditions, including various cancers, 

coronary artery disease, altered plasma lipid levels and neural tube closure defects, as well as

 thrombophilias, fertilityr Problems and complications during pregnancy.


However, despite the vital role of folate and MTHFR in its metabolism, scientific findings remain

 inconsistent and without statistically significant evidence that these polymorphisms have an

 impact on routine clinical practice. In this context, the American College of Medical Genetics

 and Genomics does not recommend the determination of the two common polymorphisms

 on a routine basis, and likewise, the American Academy of Nutrition and Dietetics does not 

recommend dietary interventions. This is because both variants have high frequencies in

 the general population, and there are no clinically meaningful interventions that can be

 offered to carriers, so their identification is not currently useful.




In addition to diet and other pathophysiological conditions (hypothyroidism, renal 

insufficiency

, arterial hypertension, diabetes mellitus, smoking or physical inactivity among 

others), the genetic

 component can affect homocysteine levels. The two widely studied common

 variants, C677T and

 A1298C, have been linked to a decrease in the activity of the MTHFR gene, which

 codes for the

 methylenetetrahydrofolate reductase enzyme involved in the folate cycle, which

 could affect 

intracellular folate distribution and increase homocysteine levels moderately.

 Both variants are

 prevalent in the population as a whole, both single copy or two copies of 

either variant, and 

one copy of each of the two variants.

Number of observed variants

13.5 million variants

Number of variants analyzed 

in the study

2 variants

Bibliography

MTHFR genetic testing: Controversy and clinical implications.

 Australian Journal for General Practitioners 2016; 45(4):237-240.

Wan L et al. Methylenetetrahydrofolate reductase and psychiatric 

diseases. Transl Psychiatry 2018; 8, 242.

Leclerc D et al. Molecular Biology of Methylenetetrahydrofolate

 Reductase (MTHFR) and Overview of Mutations/Polymorphisms. 

Madame Curie Bioscience Database [May 2022].

Liu F et al. 5,10-methylenetetrahydrofolate reductase C677T gene 

polymorphism and peripheral arterial disease: A meta-analysis. 

Vascular. 2020:1708538120982698.

Osadnik T et al. Genetic and environmental factors associated with 

homocysteine concentrations in a population of healthy young adults. 

Analysis of the MAGNETIC study. Nutr Metab Cardiovasc Dis. 2020;30(6):939-947.


TELLMEGEN.COM was used to create this report for science to use on my DNA

that is above. Hope this can help others.

Sunday, October 2, 2022

Mushrooms for MS. November 2022



                                            https://en.m.wikipedia.org/wiki/Hericium_erinaceus


Weird to think a plant, a fungi, could have benefits.  There is little to no studies done on my condition, which leads me to mushrooms, End of 2022.


My latest Diagnosis of the MS,  I have not told anybody about, as a year has gone by. A second phase is about to start. In the meantime the first phase of MUSHROOMS is happening.


Can I expect a cure? Probably not. Could they help other parts of MS? Perhaps, perhaps not.

I am talking of just some certain strains, that my neurologist knows others with MS are trying.  Its like a blind study, using the real mushrooms. You can study up on them, their technical items.

I will try blogging about each strain, perhaps the names, and technical usage expected or experience with the Mushroom, as I take one or combination  or of different Mushroom combinations.


Now, you can not just go out and buy the Mushroom to eat. Does not work that way.

Like other herbs used, the extraction process is a key factor. Some off the ones I found have done this for you.

 Exracted with hot water and alcohol (dual extraction) must take place


You can find many mushrooms on the internet.  Make sure you are getting high quality pills or powder to use. These can be added to smoothies, coffee, baking, ect.

  • Made from 100% organic mushrooms
  • Extracted with hot water and alcohol (dual extraction)
  • Made from Certified Organic mushrooms
  • Gluten-Free, Non-GMO, Vegan
  • >15% Beta-glucans, >4% Triterpenes
  • No added starch, mycelium, or grain of any kind
  • Verified for quality at accredited 3rd party labs


As always, I am not a medical Doctor, and Mushrooms need to be gone over with your Doctor.


I found a few sites quite quick that have Real Mushrooms. Let me know if their are better sites to buy from.





Science Direct has interesting article, as it applies to MS and pathways that get broken by this disease.

Therapeutic applications of mushrooms and their biomolecules along with a glimpse of in silico approach in neurodegenerative diseases

https://www.sciencedirect.com/science/article/pii/S0753332221001621#:%7E:text=It%20reported%20that%20many%20mushroom,attacked%20by%20the%20immune%20system



Lion’s mane and multiple sclerosis: Is it effective?

Medically reviewed by Heidi Moawad, M.D. — By Caitlin Geng on August 

https://www.medicalnewstoday.com/articles/lions-mane-and-multiple-sclerosis



And of course Dr Terry Wahls,MD

https://terrywahls.com/ms-management-and-my-medicinal-mushroom-trio/



Thanks for reading.

Join my Facebook page,

Leave me a message

joey

Everchangingms@gmail.com

Sunday, September 4, 2022

Multiple Sclerosis 2022 has a year made it thru?

 



Seems my blogs get far and few.  Many reasons. More Specialized Doctors added, some top of the top working with me.  I had the pleasure of meeting one, who came out of retirement, to work his specialized clinic once per month. A six month wait to get to talk with the Dr, and two others, plus student learning, as I was listening also.

These Drs specifically specialize in one field. Like one box you do not stray from. So he did not know of other diseases, just generally.  I was his first MS Patient in all his years.

Excellent at his knowledge. That was what he was teaching me in the hour spent. He did a lot of reflexes and watched me walk, talk, movements.  A new toy to "try" for five minutes a day, perhaps 15 minutes.  That was the only thing left he could offer.

My MS specialist is awaiting a new mylan repair medicine.

The Day before, I saw my MS Botox neurologist. He had a new Dr with him. I let the new Dr put the botox into my muscles. He was not afraid to ask for assistance finding muscles, asking my main Dr there. I look forward, as these shots help me stay active and walking.   I have to sign a Black Box Warning for this medivine.

I have been seeing this top dr in his field and his co Specialist and his team for this last year. They were able to bring my blood pressure and all readings into a normal range. half of what it was.


 I brought my iron up into normal range, by stopping curcumin turmeric for a day, eating beef liver ( high in Iron ) and back onto supplement. Retested, and my being iron deficient for three years after my phlebotomy or vein puncture, all went away.


                                                         Yes a DROP in blood readings

Now I am not a Dr, but would of liked to of been a birdie listening in on how Drs (in their own boxes) can disagree on symptoms and what even their test may say is going on with me.  The phone call to all these other Experts in their own field., and their perspective, or what left is a option.

All I can share now is I have Primary Progressive Multiple Sclerosis. This is effecting my whole body, in ways I would never imagine. Hereditary Hemochromatosis with the H63D H63D gene playing a role, overlapping Endocrinologist, hematologist, Neurologist,GI, nephrologis,, and 23 more to list. That are overseeing My Multiple Sclerosis. A good team. The Best of the Best.

I still walk with a cane. Minds active. get around, fatige real easily.   Research what Dr, their thoughts, brings me back to a reality, shared with only a few this entire year, of what they see, or know.  The changes a reality.


Thanks for reading 

Joey

,

Wednesday, August 17, 2022

Vitamin D and coimbra protocol

 

I can not say this better than the source. I've mentioned this in the past, but its been a while ago.






Vitamin D and coimbra protocol



https://www.coimbraprotocol.com/general-information


https://www.coimbraprotocol.com/general-information





Sunday, July 24, 2022

IRON. IRON H63D gene Hereditary Hemochromatosis

      Its been a while, but refresher course in iron.   A double H63D gene was found  in 2018. A rare for it to overload iron over load, but did. 17 trips to phlebotomist, or vein puncture, to take blood from me. see prior posts.

Do labs every three months. I was left iron deficient for three years. I found if I stopped my turmeric curcumin regime  a day, and ate beef liver with onions, and restarted my regime, it brought my iron back into balance in 2022. A trial and experiment.

 As there had to be a way to close the iron valve.

Since I have Primary Progressive Multiple Sclerosis, some items get blamed, where there may be a different diagnosis. So thus bouncing between Drs, who all have their own theory.  Last October 2021, my hemoglobin was high again. To many red blood cells, or to large.  Thus prior you tube videos to explain. But No Iron to dispose of with a phlebotomy. 2022 was year I got iron increased, by trial. And testing.  A three year low, or anemia that played a part.

Labs again in a few months, to check, and double check endocrine system. A protocol, a Specialist put me on last year  in 2021 helps tremedously but that's for another blog.

I receive Botox every three months. Injected deep into calves, inside and out, thigh muscles, and into neck muscles on both sides, and into right shoulder. The right arm was added last time.  Another blog to talk about, but helps a great deal.


But I did not want to loose these links that help understand... Just more info to listen to.

        

Iron Deficiency Without Anemia – Common, Important, Neglected



        Transferrin   Saturation





Another great site I found on iron, and related diseases

http://checkiron.com


                                                       Iron Physiology





Gastrointestinal | Liver Metabolism, Protein Synthesis & Storage


   


Approach to Anemia


Join my blog, so I know my readers!

JoeY

Wednesday, July 20, 2022

Neurologist and specialized Drs

 






Every Dr has their Speciality that I see for multiple conditions. The year 2022, made it this far with Primary progressive Multiple Sclerosis.  Awaiting new medicine to come out, as my body makes everything off the table, except Copaxone and twenty plus medicines.

So I stick to what is working thru my lengthy list of medicines, and what they are used for. Vitamin D3 in high doses, followed by endocrinologist every three months. A GI Dr, A Kidney Dr, A Heart Dr, a blood Dr, a endocrinologist, Eye drs, The list goes on.

A B12 test was ordered to check my levels, as they were low a few years ago. This you pee out any extra.  I see my blood Dr in a few weeks, as B12 can also make more red blood cells. I wonder about my other B vitamins. I do not need more red blood cells, as that makes more hemoglobin, which in turn bounces me back to another Dr.

I was on high dosage of Biotin a few years back, vitamin B7.  I measured pure powder on a scale, following study, but on real biotin, followed by endocrinologist.  The vitamin affects many lab test, and I had to stop for my endocrinologist. The high dose biotin trial, never panned out with good results anyways.

Currently my labs look good, but adding in certain vitamins could cause problems.  I have hereditary Hemochromatosis, with the Rare H63D genes, both gave me iron overload in 2018/9.  I did 17 phlebotomy or veinpuncture to resolve the iron, but that left me iron deficiency for three years. That has its own set of problems, of Anemia, and items shown how blood is made from the bones.  I will have to go into detail in another blog.


Anyways, being unique in getting all the side effects of medicines, especially generic, My team works hard to ensure I stay on name brand.

A Testosterone test came back with erroneous readings. My Dr thought the batch that my pharmacy sent was bad. She made three attempts at over a hour each to get a replacement medication.  They decided to play Dr, and Not Send any new unit, so I could retest. Every day she sent a new prescription in, talking to pharmaceutical department, it put them shipping out the next 90 day order by a few days, of when my regular order was due. Three long emails were sent from me also about the problem, that they answered to call them again.  This comes to who is playing Dr.  

My three month labs will come due, right before my next shipment comes. A waste of resources, from the drs, the labs, The largest mail order pharmacy. They asked if I wanted to file a complaint. Hmm.. "Like bitting the tail of the Dragon that feeds you"



Photo credit wixmp.com

Back to Experts I utilize at UC Davis, Sacramento. Many items have been added to my MS over the last ten years.  I lost count, at over twenty experts looking into certain areas that has a cause and effect.  I do much research giving experts a a different viewpoint sometimes on new studies or of which came first, as their is no cure.
This blog, to help keep scientist and followers updated to a point.


A lot has gone on this last year, I may write about in another blog, but being bounced around like a ping ball between Drs right now. Just not much research has been found because of my unique mess, of different specialists needed. Was offered two new ones, but have declined until I get my other specialists updated and involved.  
Everything takes time.



Joey