Hypogonadism and the risk of rheumatic autoimmune disease.

https://www.ncbi.nlm.nih.gov/pubmed/27325124
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544431/
https://arthritis-research.biomedcentral.com/articles/10.1186/ar328

Immune Modulation And Increased Neurotrophic Factor Production In Multiple Sclerosis Patients Treated With Testosterone

The role of testosterone in MS risk and course

The following charts were compiled over eight years bringing us up to date
Note the Testosterone low numbers would represent the lowest I would drop between injections.
This Study started 2012 to present. The testosterone was stopped for a MRI of Pitulary Gland.

The Cancer Dr found two copies of the H63d Gene mutation causing Iron overload. This is listed in NORD, as a rare gene. 17 phlebotomy took place over three months. Hemaglobin, transferrin, and other labs available by email request.

These are lab reports from total testosterone.
Testing procedure changed April 06,2020 .

was changed to do testosterone after 4th day of injection. All others were tested with one week off inbetween injections to see the curve of the lowest point going, Weekly or every other week, as shown in notes, as started every other week, Changed to weekly, as lowest curve was to low for drs.

Note Achtar, used for MS, raised testosterone, as a hormone.
3/07/16 Testosterone went to weekly shots. Everything before this was every Other week.
Other items listed are reference points of other test done and diagnosis reference points. Dr names have been removed for privacy.

Apr 6, 2020 7:16 AM
1,008 ng/dL
Mar 16, 2020 7:30 AM
127 ng/dL
Sep 23, 2019 7:58 AM
396 ng/dL
Apr 22, 2019 7:55 AM
528 ng/dL
Mar 4, 2019 7:30 AM
374 ng/dL
Dec 3, 2018 8:08 AM
457 ng/dL
Oct 22, 2018 7:55 AM
676 ng/dL
Jun 12, 2018 7:00 AM
71 ng/dL
Jan 25, 2018
76 ng/dL
Sep 17, 2017 7:00 AM
246 ng/dL
Sep 12, 2017 7:00 AM
246 ng/dL
Jun 22, 2017 7:00 AM
222 ng/dL
Apr 3, 2017 7:00 AM
1,686 ng/dL
Mar 30, 2017
1,636 ng/dL
Oct 3, 2016
265 ng/dL
Feb 18, 2016
175 ng/dL
Feb 12, 2015
12 ng/dL
Dec 16, 2014
143 ng/dL
Dec 3, 2014
143 ng/dL
Sep 8, 2014
1,053 ng/dL
Sep 5, 2014
240 ng/dL
Aug 11, 2014
1,014 ng/dL
Aug 7, 2014
1,163 ng/dL
Jun 3, 2014
1,052 ng/dL
Mar 3, 2014
405 ng/dL
Dec 11, 2013
91 ng/dL
Sep 5, 2013
240 ng/dL
Aug 30, 2013
240 ng/dL
Jun 12, 2012 2:05 PM
177 ng/dL

About Total Testosterone (blood)
Total Testosterone is an androgen hormone. A blood test is done in males and females to evaluate sexual dysfunction, fertility problems, premature or delayed puberty, virilization in women and as a marker for polycystic ovary syndrome (PCOS). Levels will vary by age. This data is self-reported by patients on the basis of laboratory testing.
---------

Alergic tramidol, carisoprodol
Cymbalta works. Duloxetine Actavis, bad reaction 50%, Teva brand 60%. Do not give either sub brands. Lupen working 11/17, Changed formula, not working..

Allergic to fenofibrate. Increased creatine 2019-2020

wrong diagnostic Complex regional pain syndrome RSD

Mir neck dec 27 2011
lesep and arm test March 29 2012
Mir lumbar spine may 17 2012
blood test June 5 2012
eye dr June 27 2012 alt exotropia
blood tests July 2 2012
Mir brain July 18 2012
spinal tap Aug 1 2012
ms treatment botox September 13 2012
cervical degeneration disc disease &
Multiple Sclerosis diagnosed by neurologists Dr
eye ophthalmologist Oct 20 2012
Copaxone start November 10 2012
botox Dec 13 2012
Ver Lesep test Dec 19 2012 failed
Mj switching to generic cymbalta 2/13/15 clinic saving money******
b12 injection Feb 22, 2013, nuvigil. Had to have b12 before test
botox March 14 2013
Dr. New heart Dr heart may 30 2013 refered by dr
Dr 6/6/13 notes Optic Disk Pallor and Right lateral gaze nystagmus
6/28/13 Mitral valve prolapse dr
8/12/13 botox
9/13 1 ml /week
10/01/13 medicare + medicaid
10/04/13 flu virus vaccine
10/02/13 TCL and EEG done
10/17/13 botox, EKG, Nuvigil10/19/13
11/05/13 testosterone level check quest
11/26/13 Shingles Vaccine
12/11/13 labs, tsh. testosterone=91.5 ,
1 mg inject
12/2 12/25 0.5 injections
12/26/13 Botox neck calves
1/8/14 injections .75 results= 91.5
2/4/14 testosterone injection to 1.0 ask next month for labs
Testicular Hypofunctionon going on
Feb-04-2014 Umbilical HerniaFeb-04-2014 -Pharyngitis, Acute

2-19-14 start 40 mg copaxone NEW
2-20-14 Dr. umbilical Hernia San Andreas. Blood work EKG done,
Tetnas Shot
3-03-14 quest testosterone tests
3-11-14 hernia repair Mark Twain Hsptl
3-13-14 Botox, r neck, l calf, eyes above
3-13-14 Lower Extremeties
3-18-14 re-Start 20 mg Copaxone
3-25-14 Swallowing Study Sutter Amador Hospital
12/15/14 testosterone to 1 1ml every 2weeks
Esophageal Motility Disorder Dr
04-1-14 Depo-Medrol 80 mg & pill Dr
METHYLPREDNISOLON
04-19-14 Dr opthamology
5-01-14 prostate check,&lab
. thickners added to drinks.
5-21-14 botox neck, head, outside right leg
6-03-14 blood test quest ALL
6-04-14 ACTHAR 5 day injection *Raised Testosterone
6-12-14 Lower Extremities
8-04-14 Botox neck, both calfs
8-06 14. blood: acth,testosterone, tsh &t4, hemoglobin a1c, cmp, cbc, lipid, estrogen. =1,163 ng/dL
9-08-14 blood. testosterone, cbc,psa. =1,053 ng/dL
10-13-14 botox both calfs inside/out
10/15/14 Testosterone change 1/2 ml per Dr @1153
10-24-14 flu shot
12/03/14 lab testosterone. =143 ng/dl

12/23/14 Botox neck, both calfs
12-25-14 right chest arm muscle spasms 15 days . Dr informed
1/5/16 sent saliva sample for DNA testing
1/16/15. Costochondritis per Dr said torn rotator cuff.
3/9/15. botox neck right, right outside calfs, left inside calf. EMG done scan lower extremity
3/20/15 All Labs done
5/14/15 testosterone inject 1.5ml dose new. Level = 120 ng/dl
5/26/15 Botox both calfs, neck
6/23/15 testosterone test. Testosterone = 411
7/11/15., ucdavis tests
7/13/15
labs for UCdavis viti!ine D, B, CBC, varicella sister, heptic function, basic metabolic,
7/24/15 Dr SAC heart EKG, Echo Gram high pulse
8/10/15 vit D=14 (30-100) wants increased to50,000 iu/week
8/11/15 Botox Dr left, right calf's, neck
8/11/15 vit D=13 (30-100) b=262 (200-1100). ADDED 5,000iu vitamin d3
8/14/15 thru 8/21/15 wore heart monitor cardiac event recorder Dr , Sacramento Heart OK avg pulse 80
9/09/15 start 1000 B12
9/14/15 Quest vitamin D check ucdavis
Vit D =38 (30-100)
9/15/15 SEP test Dr
9/28/15 labs vit B, D, CMP

Vit D= 50. (18-72) Vit b12=396 (200-1100)

9/28/15 ADDED 5,000 vitamin B daily
10/12/15 Flu shot
11/12/15. Botox Deep neck right, both sides neck left calf inside, right calf back. ADDED 7,000 vit d.
11/16 Dr. Still doesn't want to do anything. Said rotator cuff may be torn last month. Doesnt want to do anything. Should of prescribed valuim three months ago.Valium was prescribed for muscle spasms
12/17/15 Ampyra started
Dr wants cmp,cbd, vit b, D, testosterone read feb
1/4/16 Dr refused blood test, didn't want liability. Told him to contact specialist.
1/4/16 Osteoarthritis in left elbow nodules Dr nothing done.
1/4/16 Tmj in left jaw mills did nothing
2/11/16 botox
Dr injects right Left neck, left calf botox.
Emg of heart
2/12/16 labs per two drs
CMP, testosterone total, urinalysis complete,CBC inc diff pot, bit b13, folate, serum panel, PSA, total, Lipid Panel, Vitamin D, 1,25 dihydroxy lc/ms/ms, Tsh and free T4
2/18/16 new GP Dr. Sample of 75 mg viberza given for diahrea. Got blood test
2/18/16 . vit d=52. Vit B= 1409
testosterone= 175
3/01/16 blood flow of brain Dr. Added nuedexta sample for quinine.
3/17/16 referral to GI. Dr May17 Viberzi 100 mg given 2xday.
Increased testosterone 1ml every week. 3/26 4 bottles
4/08/16 ucdavis did chest xray Sacramento findings: Dextroscoliosis dextroscoliosis of the
thoracic spine is noted.

Increased vitamin d 50,000 twice per week, use b2, 6, biotin try all Bs
4/11 switched to Walmart pharmacy all drugs.
5/02/16 Dexta scan sutter amador -.7 is low enough.
5/02/16 pth level blood sutter amador, cough sample.
5/23 labs per UC Davis long chain fatty acid test UC Davis Dr ,, vitamin D cmp, vit b standing order
5/25 start RISEDRONATE soDIUM 35MG TABLET for bone loss
5/26/16 upper and lower colonospopy Dr
Sacramento. Upper flap ulcer, report Sutter health.
COLONOSCOPY W / OR W /O INTERVENTION performed by DR
ESOPHAGOGASTRO DUODENOSCOPY (EGD) performed by DR
When:
Thursday May 26, 2016 9:00 AM
Ulcerative Colitis and hiatial hernia
5/27 Friday. Copaxone delivery, knots in calfts, right leg hurts,, shoukder
6-01 Dsl#3 450 billion probiotic start 6/01. $88 cosco paid
6-3-16. Prednisone 20 mg start 6/3/16 three times day for three days. Sauer
NEW RANITIDINE HCL 150 mg for irritated stomach found.
150MG TABLET Dr
6/27/16 applied to NORD for DSL#3 DS
7/11/16 steroid injected by Dr right shoulder neck. Relief!!
synthetic glucocorticoid corticosteroid Triamcinolone 10mg
Lasted four days
7/21 thyroid checked. Calcium blood test. Endocrinology ucdavis. Increased vit d to 150, 000 for three months, then blood/ urine test. Dr ucdavis
8/08 antibiotic Dr for green slime coughing up levofloaxacin
8/11/16 botox to upper right shoulder neck, both calves Dr
8/20/16 three day round prednisone oral, once antibiotic was done.
9/07 botox booster outside left leg. Dr
9/10/16 flu shot given by pharmacist
9/28 lower extremities test, blood flow test
10/03 labs test Dr . Calcium. Vit d2, albumin,creation&calcium 24 hr urine. CBD Cmp by Dr
10/21 stopped B vitamins, not doing anything. Lowered D to 100,000/week D=91 ask gp on testosterone low testosterone= 265 per Dr uc davis
11/07/2016 Dr increased testosterone to 1.5 ml/ week
11/09 applied to more for another year vsl#3 D's accepted

11/10 botox Both inside calf's, right neck muscle
11/12/16 100mg pure Biotin three times day. Scale to measure
MD001 trial
https://purebulk.com/biotin-pure/ Dr anducdavis, dt
11/22/16 uc Davis MRI cspine and brain Dr
1/11/17 flue with green all month
2/06/17 Dr evoflaxin500 for10 days, cough syrup
2/07/17 Dr . Botox both calf's and neck muscle twice for right shoulder. To add zinc to diet. This area on neck did trick
3/06 bactrim 10 days plugged me up. Dr
3/17/17 Dr EKG, yearly visit
3/30/17 Dr to stop testosterone shots. Do a bunch of labs before seeing her in three months.
Increase to 150,000iu/week vitamin D level dropped from 91 to 63
Test: total testerone,sex hormone binding,hemocritin, PSA, luteinizing hormone, folic stimulating hormone, prolactin, thyroid stimulating hormone, thyroxine free, misc lab00041 IGF-1, cortisol, vit D, magnesium. Three monts
increased got D to 150,000iu week also
Stop testosterone 3 months so labs of hypothalamus, pitulary, testes,
Stopped md1003 for testing
4/01/17 Dr yearly opthalmologist exam
4/03/17 Dr lab test CBC, Comp metal,lipid panel w ratio t4 free, testosterone, tsh fasting test
4/05/17 increase vsl#3ds 1 package per day dr 950 billion
4/07/17 cyst drained left wrist Dr
4/08/17 Dr levoflaxin500 for10 days, for green phlem cough
4/10 Dr neurologist UC davis, about samr
4/26 sent Dr MRI disc to compare
5/04/17 UBIOME gut bacteria sample, registered to mail
5/08 Botox Dr neck both sides, middle, both inside calf's. Can see muscles hard.
6/1/17 patients like me pioneer in research consent blood draws
6/07/17 Dr booster botox x left calf.
6/ /17
Am doing ESR,CPK,vite,HHV-6 virus,testosterone, sex hormone binding glob, hematocrit,PSA,luteinizing hormone,follicle stimulating hormone, prolactin, tsh,thyroxine free,igf-1,cortisol,vitimin D,Magnesium on upcoming labs, thus why off testosterone therapy. Hypothalamus -pitulary gland-testes loop and thyroid
6/19, 6/21, 6/22, labs for drs. Had problem with ana panel test, and cortisol. Not their responsibility. Did not know what checked box mention.
B7/03/17 Dr doing MRI of pitulary gland keep 150, 000 vit D level 83,
Testosterone restart after MRI.
7/04/17 Started back md1003 Biotin, added LENTLES to diet
7/07 Dr ALA α-Linolenic acid (ALA). try http://www.medicalnewstoday.com/articles/318225.php
7/11/17 MRI of pitulary gland Dr UC davis. Pitulary fine
7/12/17 Hypogonadotropic hypogonadism
7/12 start 1 ml testosterone per week. Level below 211
7/24/17 blood draw for patients like me. Edta plasma, pax gene,serium red top, RNA DNA four tubes
Alpa lipoic Acid 600 mg twice daily. Start7/26/17
8/11/17 have rash woke up to on groin, buttocks, 8/12 moved to waste line, back and arms. Still moving around. Rash on buttocks, spread to groin, then hives moved around on arms and leg muscles thru 6 am 8/15
8/15/17 botox Dr both legs. Spasm found. Right rotator cuff, muscle high on neck. Refills in 3 weeks.
8/18 muscle spasms quite sore from botox. Neck shoulder sore spasms
8/19 picked up Monday 8/21 Ingenious Modafinil. Generic change of name from cephalon modafinil provigil written.
9/12/17 fasting blood test ucdavis for Dr. Dr go over shoulder, gut pee test on Sunday.
10/05/17 more endocrinologist blood test UC Davis. Note Biotin taken in am 100mg messes with tests. Took Sunday tested wed am
10/05 Dr uc Davis drop testosterone to 1/2 weekly. 140,000 iu vit D. Told her I took Biotin that morning, and was dehydrated last test, and biotin not stopped soon enough. Retested four test. Thyroid came up high because biotin. Hemacrit within levels..hydrated.
10/06 D did liver panel on me at Sutter hospital. Ok good result
NEED IRON, FERRETT ran 11/06 fine
10/09/17 added chicory root 1/2 tsp-1tsp
10/21/17 flu shot
10/27/17 EKG Dr . Increased clonidine from .2 to .3
11/06 labs Dr. Cbc, ferritin, , iron, liver.
Ordered MRI of spine neck
11/08 MRI spine Sutter hospital
11/10 two page report on pinched nerves. Called, ucdavis let known
11/12/17 added corn pre biotic
11/15 Botox Dr Would not look at neck report
11/21/17 blood draw patients like me TAD
12/4 Dr Mad he did not see me souoner. Need referral Dr for epidural injections.
12/4/17 Dexamethason 4mg. Two tabs 4 days, the 1 tab 4 days to relief pain from disc pinching nerves 12/04/17 bowhay
12/07 called for referred again.
12/07 Dr optic neuritis left eye. New glasses, 2 hrs spent

12/14/17 Dr to go over botox
12/14/17 Dr went over MRI notes and eye notes. Sent e home with bottle of hyaluronic acid
12/26/2017
12/26 epidural Placerville 80 mg prednisone into neck. Did not work he called 1/09/18
Dr epidural injections.
El Dorado Surgery Center
Sutter Amador Dr treating optic neuritis with 1,000 mg Methylprednisolone 12/14/17 5 days iv solution Dr , optic neuritis injected iv for Thur, Fri, Mon, Tue, wed
12/26 epidural Dr 80 mg prednisone into neck. Did not work he called 1/09/18
2018
1/3/18 Ubiome study of gut sent in #3
New GP from clinic. ----
1/09/18 Dr
Subject: Referal referal to us davis for spine institute
1/25 blood fasting at ucdavis cbc,cm p for dr 730
1/25 Dr MS clinic midtown 11am, not enough time. see her six months
2/01/18 Dr was 150,000 iu D/week,level 86, 2 ml testosterone lweek level54
2/07 Dr added Simethicone to daily for bloat
2/15 u c davis spine Wants four fused. 5 minutes, no q&a
3/1/18 postponed surgery indefinitely four disc Dr wanted fused .
Note 1/3/2020 not candidate for any surgery
3/2/18 Dr ekg. High triglycerides from pasta, bread, sweets, wine day before. Not worried. Him and Dr sidhu glad not doing surgery.
5/15 added 400 mg hyaluronic acid pe protruding
5/17/18 botox both calfs, upper right neck to right arm muscle
6/01 Psylium hull added
6/02 18 hyaluronic acid London is 300mg
6/6/18 hepatitis c antibody test .16 ratio who c ab non reactive
Hemoglobin test e at 111 diabetes non, less 5.5
6/07 hernniha large protruding. hemorrhoid per Dr picture sent
6/12 lab test UC Davis, botox extra ink left calf
Joined all of us research
6/14 vi t D=72 take 140,000 iu week
Testosterone level #71, taking 2.0 ml week, dropped from #76 from last test.
pth was 12 in May 2016,
blood calcium 10.4 on 6/2018--------------------------------------------
Lowered D in 1/2, testosterone to 1.5
6/22/18 end of test of 300 mg Hyaluronic from London and Hyaluronic acid 100 mg form Dr =400 total. START test of 450 mg Hyaluronic Acid and 600 of chronodition together
6/22 hemorrhoid inside also. Butt black left side. Used fluoinocide.
7/12 Dr referred me to hematology blood specialist. Primary Polycythemia. Hypochondriac in male. Vitamin D deficiency. Put me back on 2 ml testosterone and 150,000 vi t D
8/8/18 Dr , UC Davis cancer Polycythemia primary center blood test, curriculum econ 9 mutation,cbc with diff, cmp,erythropoietin, ferritin, iron, jak2 mutation, lab misc, transferrin.
8/15 /18 botox calves and neck DrTold he add baby asprin, upon telling him tests.primary
9/12/18 Dr uc davis cancer iron overload syndrome. Did cbc, hemochromatosis the gene dna blood. Ordering scan of abdomen. H63d both genes
9/14 new GI uc davis. Dr
Scan for Dr
9/17/18 Sleep study by Dr teams of paper. Joe and wil
Abdominal ultrasound is a type of imaging test. It is used to look at organs in the abdomen, including the liver, gallbladder, spleen, pancreas, and kidneys.
9/20 EKG by Dr . Went over echo and high triglyceride. Sent to Dr, before meds to lower.
9/24/18 hydrogen breath test uc davis Dr Negative for small intestine overgrowth positive for butane from constipation.
9/26/18 start Polyethylene glycol pkt 3350-rx Dr
10/01/18 phlebotomy 300ml Taken labs before and after, but diluted with saline.
To do phlebotomy Weekly. Labs taken before
10/04 TRULANCE 3 mg started Dr
[]10/05/18 Fenofibrate 145 mg started Dr for triglycerides
10/7/1 fluarixq quad flu shot
10/7/18 tetnas diphtheria a cellular pertussis vaccine
[]10/08 phlebotomy uc davis 250 ml. Looked like soft serve ice cream. This being done weekly
10/10 labs, Dr 3pm. Iron overload is rare in patients homozygous for the H63D mutation
10/11/18 botox both calfs. Hard as rock. Neck muscles also Dr
12/03/18 labs Dr . Vitamin D stopped for last month went from 104 to 43. Calcium 10.0.
Still phlebotomy weekly.
12/06 Vitamin D at 70,000 it week, testosterone at 1.5 per Dr
12/14 metoclopramide added back in Dr. Th I is iron is overloaded and in pituitary gland, liver, as ferritin came down in level, but hemoglobin still high. Referral to liver dr.
metabolic disorder. Liver Dr did nothing.
Still phlebotomy weekly
1/2/19 last phlebotomy stops, as now anemic
2/26/19 changed from Trulance to linzes Dr
3/13 testosterone increased by.25 to 1.75 ml. Vit d from 70,000 to 140,000. 374t 47 d
3/18/19 lsep test Dr
4/19/19 Limon changed formula for duloxetine. Took it off 1 month. Not as strong. Lasting 18 hrs
5/06/19 botox both calls and neck
5/18/19 eye exam Dr
5/06/19 botox both calfs and neck
5/18/19 eye exam Dr
5/30 19 booster inside left leg botox. Ask about a new MRI in August
7/30 request increased duloxetine 30 grams more for pain.mood
8/06 botox Dr
8/29 booster shot two areas left leg sauer. Magnesium 400mg added
9/07 flu shot
9/23 added probiotics per GI Dr align and Phillips colon
10/01/19 added 180,000 vit D per , retest three months. Stopped fenofibrate
10/07 tests Dr
Blood test per Dr c.f. To Dr
10/11 Dr dyslipidemia, high triglycerides. Fenofibrate caused spike in creatine up to 1.84
Change to blood control med and vascepa
10/16/19 manometer uc Davis dr. fleet enema before.
12/02/19 blood test and dr
12/10/19 added 65 mg Iron every other day, as still anemic from blood test
12/19/19 MRI brain and spine Dr
Tachycardia
12/26/2019 did Viome.com test of gut to help with food map, and recommendations, for stomach detailing since phlebotomy
12/26/2019 did tellmegen.com DNA test, to see if other diseases, check DNA, and check medicines of how they work within my DNA Pharmacogenetic

1/1/2020 new drug coverage plan
1/2/2020 called by insurance about dopamine and second call for ampyra.
1/6/2020 Dr go refill. Had influenza vaccine for double strength, and
Pneumococcal conjugate vaccine. Pv13
1/8/2020 CMP done by dr nurse neurologist
2-2020 mild kidney impairment. 1.87 high creatine
1/19/2020 started Name brand CYMBALTA
1/23/2020 MRI t spine . No ms
Vertebral body heights and marrow: Multilevel thoracic spondylosis with
osteophytes, facet arthropathy. Minimal degenerative endplate changes at
T12-L1 anteriorly
Artifact across the upper thoracic cord is seen outlined by an arrow
(series 7 image 13).
2. Mild degenerative changes within the thoracic spine.

2/12/20 UC Davis injected botox into both calves, into both sides of neck more on right side. Used guidance machine. Had grad student with him. 2 hrs spent. Head not had botox in six months
Had to get approval for botox. Botox lasted 54 days before major Charlie horse, neck spasms.
2/01/2020 (HCC), Cervical radiculitis
Biallelic mutation of HFE gene
3/14/2020 updated shingles vaccine. Need redone two months
3/16 blood test Dr testosterone 1.0 ml down from 1.75ml
3/23 Dr and Dr by video chat. Question on testosterone amount came up.
3/24/20 sent over all meds with pharmacy. Forgot needles. Tellemedicine chat
4/10/20 testosterone changed to 0.5ml from 1.0 on 3/16, was 1.75 for weekly 3/13/18
Total T=1008

Thank you for reading, please email me with specific questions or other links I can Add, or if others have had high testosterone therapy that has helped
EverchangingMS@Gmail.com

Stay safe out there with covid-19 going on.
JoeY

Ever Changing MS

Search This Blog

Monday, April 13, 2020

Testosterone and Multiple Sclerosis

Hypogonadism and the risk of rheumatic autoimmune disease.